The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1.

The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1.

Hypoxia has been shown to promote tumor metastasis and lead to therapy resistance. Recent work has demonstrated that hypoxia represses E-cadherin expression, a hallmark of epithelial to mesenchymal transition, which is believed to amplify tumor aggressiveness. The molecular mechanism of E-cadherin r...

Полное описание

Библиографические подробности
Главные авторы:	Schietke, R, Warnecke, C, Wacker, I, Schödel, J, Mole, D, Campean, V, Amann, K, Goppelt-Struebe, M, Behrens, J, Eckardt, K, Wiesener, MS
Формат:	Journal article
Язык:	English
Опубликовано:	2010

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