Activation segment exchange: a common mechanism of kinase autophosphorylation?
The crystal structure of the kinase domain from human checkpoint kinase 2 (Chk2) has shown, for the first time, the reciprocal exchange of activation segments between two adjacent molecules and provides the molecular basis for understanding the observed mode of Chk2 kinase activation via trans-autop...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2007
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