Activation segment exchange: a common mechanism of kinase autophosphorylation?
The crystal structure of the kinase domain from human checkpoint kinase 2 (Chk2) has shown, for the first time, the reciprocal exchange of activation segments between two adjacent molecules and provides the molecular basis for understanding the observed mode of Chk2 kinase activation via trans-autop...
Main Authors: | Oliver, A, Knapp, S, Pearl, L |
---|---|
Format: | Journal article |
Language: | English |
Published: |
2007
|
Similar Items
-
Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites
by: Pike, A, et al.
Published: (2008) -
Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites.
by: Pike, A, et al.
Published: (2008) -
Autophosphorylation and Self-Activation of DNA-Dependent Protein Kinase
by: Aya Kurosawa
Published: (2021-07-01) -
A critical evaluation of protein kinase regulation by activation loop autophosphorylation
by: Ronja Reinhardt, et al.
Published: (2023-07-01) -
Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2
by: Adelajda Zorba, et al.
Published: (2014-05-01)