Defective Cytochrome P450-Catalysed Drug Metabolism in Niemann-Pick Type C Disease

Defective Cytochrome P450-Catalysed Drug Metabolism in Niemann-Pick Type C Disease

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Niemann-Pick type C (NPC) disease is a neurodegenerative lysosomal storage disease caused by mutations in either the NPC1 or NPC2 gene. NPC is characterised by storage of multiple lipids in the late endosomal/lysosomal compartment, resulting in cellular and organ system dysfunction. The underlying m...

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Bibliographic Details
Main Authors: Platt, F, Nicoli, E, Al Eisa, N, Cluzeau, C, Wassif, C, Gray, J, Burket, K, Smith, D, Morris, L, Cologna, S, Peer, C, Sissung, T, Uscatu, C, Figg, W, Pavan, W, Vite, C, Porter, F
Format: Journal article
Published: Public Library of Science 2016

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