Suppression of thromboxane A2 but not of systemic prostacyclin by controlled-release aspirin.
BACKGROUND: The antithrombotic efficacy of aspirin is attributed to its inhibition of the enzyme prostaglandin G/H synthase, which is necessary for the formation of thromboxane A2 in platelets. Thromboxane A2 is a potent vasoconstrictor and platelet agonist. However, the formation of prostacyclin by...
Autors principals: | Clarke, R, Mayo, G, Price, P, FitzGerald, G |
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Format: | Journal article |
Idioma: | English |
Publicat: |
1991
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