IκB Kinase α is required for development and progression of KRAS-mutant lung adenocarcinoma

Although oncogenic activation of NFkB has been identified in various tumors, the NFkB–activating kinases (inhibitor of NFkB kinases, IKK) responsible for this are elusive. In this study, we determined the role of IKKa and IKKb in KRAS-mutant lung adenocarcinomas induced by the carcinogen urethane an...

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Bibliographic Details
Main Authors: Vreka, M, Lilis, I, Papageorgopoulou, M, Giotopoulou, G, Lianou, M, Giopanou, I, Kanellakis, N, Spella, M, Agalioti, T, Armenis, V, Goldmann, T, Marwitz, S, Yull, F, Blackwell, T, Pasparakis, M, Marazioti, A, Stathopoulos, G
Format: Journal article
Language:English
Published: American Association for Cancer Research 2018