Genes encoding the Ti beta subunit of the antigen/MHC receptor undergo rearrangement during intrathymic ontogeny prior to surface T3-Ti expression.

To obtain further information about the ontogeny of the T-cell antigen/MHC receptor, a Ti beta subunit cDNA probe and heteroantisera specific for the Ti alpha and Ti beta subunits were utilized to characterize human T-lineage cells. Analysis of thymic tumors and normal thymocytes at both the DNA and...

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Bibliographic Details
Main Authors: Royer, H, Acuto, O, Fabbi, M, Tizard, R, Ramachandran, K, Smart, J, Reinherz, E
Format: Journal article
Language:English
Published: 1984