Genes encoding the Ti beta subunit of the antigen/MHC receptor undergo rearrangement during intrathymic ontogeny prior to surface T3-Ti expression.
To obtain further information about the ontogeny of the T-cell antigen/MHC receptor, a Ti beta subunit cDNA probe and heteroantisera specific for the Ti alpha and Ti beta subunits were utilized to characterize human T-lineage cells. Analysis of thymic tumors and normal thymocytes at both the DNA and...
| Główni autorzy: | , , , , , , |
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| Format: | Journal article |
| Język: | English |
| Wydane: |
1984
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| _version_ | 1826289531466285056 |
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| author | Royer, H Acuto, O Fabbi, M Tizard, R Ramachandran, K Smart, J Reinherz, E |
| author_facet | Royer, H Acuto, O Fabbi, M Tizard, R Ramachandran, K Smart, J Reinherz, E |
| author_sort | Royer, H |
| collection | OXFORD |
| description | To obtain further information about the ontogeny of the T-cell antigen/MHC receptor, a Ti beta subunit cDNA probe and heteroantisera specific for the Ti alpha and Ti beta subunits were utilized to characterize human T-lineage cells. Analysis of thymic tumors and normal thymocytes at both the DNA and protein levels demonstrates that Ti beta gene rearrangement is evident in stage II (T11+T6+T3-) and stage III (T11+T6-T3+), but not stage I (T11+T6-T3-) thymocytes. In contrast, surface expression of Ti alpha and Ti beta molecules is exclusively restricted to stage III thymocytes. Thus human T-lineage ontogeny is characterized by an orderly series of differentiation steps wherein Ti beta gene rearrangement precedes surface expression of the T3-Ti molecular complex. |
| first_indexed | 2024-03-07T02:30:17Z |
| format | Journal article |
| id | oxford-uuid:a701f415-3e47-4538-9f9c-c6629eacfa49 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:30:17Z |
| publishDate | 1984 |
| record_format | dspace |
| spelling | oxford-uuid:a701f415-3e47-4538-9f9c-c6629eacfa492022-03-27T02:51:29ZGenes encoding the Ti beta subunit of the antigen/MHC receptor undergo rearrangement during intrathymic ontogeny prior to surface T3-Ti expression.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a701f415-3e47-4538-9f9c-c6629eacfa49EnglishSymplectic Elements at Oxford1984Royer, HAcuto, OFabbi, MTizard, RRamachandran, KSmart, JReinherz, ETo obtain further information about the ontogeny of the T-cell antigen/MHC receptor, a Ti beta subunit cDNA probe and heteroantisera specific for the Ti alpha and Ti beta subunits were utilized to characterize human T-lineage cells. Analysis of thymic tumors and normal thymocytes at both the DNA and protein levels demonstrates that Ti beta gene rearrangement is evident in stage II (T11+T6+T3-) and stage III (T11+T6-T3+), but not stage I (T11+T6-T3-) thymocytes. In contrast, surface expression of Ti alpha and Ti beta molecules is exclusively restricted to stage III thymocytes. Thus human T-lineage ontogeny is characterized by an orderly series of differentiation steps wherein Ti beta gene rearrangement precedes surface expression of the T3-Ti molecular complex. |
| spellingShingle | Royer, H Acuto, O Fabbi, M Tizard, R Ramachandran, K Smart, J Reinherz, E Genes encoding the Ti beta subunit of the antigen/MHC receptor undergo rearrangement during intrathymic ontogeny prior to surface T3-Ti expression. |
| title | Genes encoding the Ti beta subunit of the antigen/MHC receptor undergo rearrangement during intrathymic ontogeny prior to surface T3-Ti expression. |
| title_full | Genes encoding the Ti beta subunit of the antigen/MHC receptor undergo rearrangement during intrathymic ontogeny prior to surface T3-Ti expression. |
| title_fullStr | Genes encoding the Ti beta subunit of the antigen/MHC receptor undergo rearrangement during intrathymic ontogeny prior to surface T3-Ti expression. |
| title_full_unstemmed | Genes encoding the Ti beta subunit of the antigen/MHC receptor undergo rearrangement during intrathymic ontogeny prior to surface T3-Ti expression. |
| title_short | Genes encoding the Ti beta subunit of the antigen/MHC receptor undergo rearrangement during intrathymic ontogeny prior to surface T3-Ti expression. |
| title_sort | genes encoding the ti beta subunit of the antigen mhc receptor undergo rearrangement during intrathymic ontogeny prior to surface t3 ti expression |
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