Severe and complicated malaria treated with artemisinin, artesunate or artemether in Viet Nam.
One hundred and seventy five Vietnamese adults with severe and complicated malaria admitted to a rural district hospital were entered into an open randomized comparative study to compare 4 treatment regimens based on artemisinin and its derivatives. The median time of defervescence was 48 h (95% con...
| Hlavní autoři: | , , , , , , |
|---|---|
| Médium: | Journal article |
| Jazyk: | English |
| Vydáno: |
1997
|
| _version_ | 1826289555866648576 |
|---|---|
| author | Ha, V Nguyen, N Tran, T Bui, M Nguyen, H Tran, T Phan, T Arnold, K Tran, T |
| author_facet | Ha, V Nguyen, N Tran, T Bui, M Nguyen, H Tran, T Phan, T Arnold, K Tran, T |
| author_sort | Ha, V |
| collection | OXFORD |
| description | One hundred and seventy five Vietnamese adults with severe and complicated malaria admitted to a rural district hospital were entered into an open randomized comparative study to compare 4 treatment regimens based on artemisinin and its derivatives. The median time of defervescence was 48 h (95% confident interval [CI] 38-58 h) in those given intramuscular (i.m.) artemether, 42 h (95% CI 36-48 h) in those given artemisinin suppositories, 36 h (95% CI 30-42 h) in those receiving artesunate (i.m.) and 30 h (95% CI 18-42 h) in those receiving intravenous artesunate (P = 0.13). The respective median parasite clearance times were 30 h (95% CI 26-34 h), 30 h (95% CI 24-36 h), 24 h (95% CI 15-33 h), and 24 h (95% CI 15-33 h) (P = 0.30); the median times for recovery of consciousness were 47 h (95% CI 31-63 h), 24 h (95% CI 18-30 h), 30 h (95% CI 18-42 h), and 24 h (95% CI 4-44 h) (P = 0.18); and the mortality rates were 11.1%, 17.6%, 10.2% and 16.6%, respectively (P = 0.64). There was no significant difference in efficacy between the 4 treatments. |
| first_indexed | 2024-03-07T02:30:40Z |
| format | Journal article |
| id | oxford-uuid:a71ffe67-1c26-4ca2-a1e7-4bd9f2a5726c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:30:40Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | oxford-uuid:a71ffe67-1c26-4ca2-a1e7-4bd9f2a5726c2022-03-27T02:52:22ZSevere and complicated malaria treated with artemisinin, artesunate or artemether in Viet Nam.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a71ffe67-1c26-4ca2-a1e7-4bd9f2a5726cEnglishSymplectic Elements at Oxford1997Ha, VNguyen, NTran, TBui, MNguyen, HTran, TPhan, TArnold, KTran, TOne hundred and seventy five Vietnamese adults with severe and complicated malaria admitted to a rural district hospital were entered into an open randomized comparative study to compare 4 treatment regimens based on artemisinin and its derivatives. The median time of defervescence was 48 h (95% confident interval [CI] 38-58 h) in those given intramuscular (i.m.) artemether, 42 h (95% CI 36-48 h) in those given artemisinin suppositories, 36 h (95% CI 30-42 h) in those receiving artesunate (i.m.) and 30 h (95% CI 18-42 h) in those receiving intravenous artesunate (P = 0.13). The respective median parasite clearance times were 30 h (95% CI 26-34 h), 30 h (95% CI 24-36 h), 24 h (95% CI 15-33 h), and 24 h (95% CI 15-33 h) (P = 0.30); the median times for recovery of consciousness were 47 h (95% CI 31-63 h), 24 h (95% CI 18-30 h), 30 h (95% CI 18-42 h), and 24 h (95% CI 4-44 h) (P = 0.18); and the mortality rates were 11.1%, 17.6%, 10.2% and 16.6%, respectively (P = 0.64). There was no significant difference in efficacy between the 4 treatments. |
| spellingShingle | Ha, V Nguyen, N Tran, T Bui, M Nguyen, H Tran, T Phan, T Arnold, K Tran, T Severe and complicated malaria treated with artemisinin, artesunate or artemether in Viet Nam. |
| title | Severe and complicated malaria treated with artemisinin, artesunate or artemether in Viet Nam. |
| title_full | Severe and complicated malaria treated with artemisinin, artesunate or artemether in Viet Nam. |
| title_fullStr | Severe and complicated malaria treated with artemisinin, artesunate or artemether in Viet Nam. |
| title_full_unstemmed | Severe and complicated malaria treated with artemisinin, artesunate or artemether in Viet Nam. |
| title_short | Severe and complicated malaria treated with artemisinin, artesunate or artemether in Viet Nam. |
| title_sort | severe and complicated malaria treated with artemisinin artesunate or artemether in viet nam |
| work_keys_str_mv | AT hav severeandcomplicatedmalariatreatedwithartemisininartesunateorartemetherinvietnam AT nguyenn severeandcomplicatedmalariatreatedwithartemisininartesunateorartemetherinvietnam AT trant severeandcomplicatedmalariatreatedwithartemisininartesunateorartemetherinvietnam AT buim severeandcomplicatedmalariatreatedwithartemisininartesunateorartemetherinvietnam AT nguyenh severeandcomplicatedmalariatreatedwithartemisininartesunateorartemetherinvietnam AT trant severeandcomplicatedmalariatreatedwithartemisininartesunateorartemetherinvietnam AT phant severeandcomplicatedmalariatreatedwithartemisininartesunateorartemetherinvietnam AT arnoldk severeandcomplicatedmalariatreatedwithartemisininartesunateorartemetherinvietnam AT trant severeandcomplicatedmalariatreatedwithartemisininartesunateorartemetherinvietnam |