Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms.

Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms.

In a previous study, we identified somatic mutations of SF3B1, a gene encoding a core component of RNA splicing machinery, in patients with myelodysplastic syndrome (MDS). Here, we define the clinical significance of these mutations in MDS and myelodysplastic/myeloproliferative neoplasms (MDS/MPN)....

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Malcovati, L, Papaemmanuil, E, Bowen, D, Boultwood, J, Della Porta, MG, Pascutto, C, Travaglino, E, Groves, M, Godfrey, A, Ambaglio, I, Gallì, A, Vià, D, Conte, S, Tauro, S, Keenan, N, Hyslop, A, Hinton, J, Mudie, L, Wainscoat, J, Futreal, P, Stratton, MR, Campbell, P, Hellström-Lindberg, E, Cazzola, M
Format: Journal article
Sprache:English
Veröffentlicht: 2011

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