Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms.

Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms.

In a previous study, we identified somatic mutations of SF3B1, a gene encoding a core component of RNA splicing machinery, in patients with myelodysplastic syndrome (MDS). Here, we define the clinical significance of these mutations in MDS and myelodysplastic/myeloproliferative neoplasms (MDS/MPN)....

Volledige beschrijving

Bibliografische gegevens
Hoofdauteurs:	Malcovati, L, Papaemmanuil, E, Bowen, D, Boultwood, J, Della Porta, MG, Pascutto, C, Travaglino, E, Groves, M, Godfrey, A, Ambaglio, I, Gallì, A, Vià, D, Conte, S, Tauro, S, Keenan, N, Hyslop, A, Hinton, J, Mudie, L, Wainscoat, J, Futreal, P, Stratton, MR, Campbell, P, Hellström-Lindberg, E, Cazzola, M
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	2011

Gelijkaardige items

Myelodysplastic/myeloproliferative disorders
door: Luca Malcovati, et al.
Gepubliceerd in: (2008-01-01)

Somatic mutations of calreticulin in myeloproliferative neoplasms and myelodysplastic/myeloproliferative neoplasms
door: Luca Malcovati, et al.
Gepubliceerd in: (2014-11-01)

Risk assessment in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms
door: Mario Cazzola
Gepubliceerd in: (2011-03-01)

Clinical evaluation of extra-hematologic comorbidity in myelodysplastic syndromes: ready-to-wear versus made-to-measure tool
door: Matteo G. Della Porta, et al.
Gepubliceerd in: (2012-04-01)

Deregulated Gene Expression Pathways in Myelodysplastic Syndrome Hematopoietic Stem Cells
door: Pellagatti, A, et al.
Gepubliceerd in: (2009)

Clonality in the myelodysplastic syndromes.
door: Boultwood, J, et al.
Gepubliceerd in: (2001)

Somatic Mutation of SF3B1, a Gene Encoding a Core Component of RNA Splicing Machinery, in Myelodysplasia with Ring Sideroblasts
door: Malcovati, L, et al.
Gepubliceerd in: (2011)

Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells.
door: Pellagatti, A, et al.
Gepubliceerd in: (2010)

Molecular basis of myelodysplastic/myeloproliferative neoplasms
door: Andreas Reiter, et al.
Gepubliceerd in: (2009-12-01)

Identification of Prognostic Markers by Gene Expression Profiling In Myelodysplastic Syndrome Hematopoietic Stem Cells
door: Pellagatti, A, et al.
Gepubliceerd in: (2010)

Molecular pathogenesis of the myelodysplastic syndromes
door: Boultwood, J, et al.
Gepubliceerd in: (1999)

Marked down-regulation of nucleophosmin-1 is associated with advanced del(5q) myelodysplastic syndrome.
door: Pellagatti, A, et al.
Gepubliceerd in: (2011)

Marked down-regulation of nucleophosmin-1 is associated with advanced del(5q) myelodysplastic syndrome
door: Pellagatti, A, et al.
Gepubliceerd in: (2011)

Neutrophil PRV-1 gene expression in myeloproliferative, myelodysplastic and reactive blood disorders
door: Zhang, J, et al.
Gepubliceerd in: (2004)

Gene Expression Profiling of CD34(+) Cells in Patients with Myelodysplastic Syndromes
door: Pellagatti, A, et al.
Gepubliceerd in: (2008)

Risk stratification based on both disease status and extra-hematologic comorbidities in patients with myelodysplastic syndrome
door: Matteo G. Della Porta, et al.
Gepubliceerd in: (2011-03-01)

Clinical and biological implications of driver mutations in myelodysplastic syndromes.
door: Papaemmanuil, E, et al.
Gepubliceerd in: (2013)

MYELODYSPLASTIC/MYELOPROLIFERATIVE DISEASES
door: I. N. Subortseva, et al.
Gepubliceerd in: (2017-01-01)

Telomere length in myelodysplastic syndromes.
door: Boultwood, J, et al.
Gepubliceerd in: (1995)

Marked downregulation of the granulopoiesis regulator LEF1 is associated with disease progression in the myelodysplastic syndromes.
door: Pellagatti, A, et al.
Gepubliceerd in: (2009)

Myelodysplastic syndromes
door: Eva Hellström Lindberg
Gepubliceerd in: (2018-06-01)

Identification of Prognostic Markers by Gene Expression Profiling In Myelodysplastic Syndrome Hematopoietic Stem Cells
door: Pellagatti, A, et al.
Gepubliceerd in: (2010)

Identification of Prognostic Markers by Gene Expression Profiling In Myelodysplastic Syndrome Hematopoietic Stem Cells
door: Pellagatti, A, et al.
Gepubliceerd in: (2010)

Frequent Mutation of the Polycomb-Associated Gene ASXL1 in the Myelodysplastic Syndromes and in Acute Myeloid Leukaemia
door: Boultwood, J, et al.
Gepubliceerd in: (2009)

Impact of the degree of anemia on the outcome of patients with myelodysplastic syndrome and its integration into the WHO classification-based Prognostic Scoring System (WPSS)
door: Luca Malcovati, et al.
Gepubliceerd in: (2011-10-01)

High Throughput Targeted Gene Sequencing in 738 Myelodysplastic Syndromes Patients Reveals Novel Oncogenic Genes, Rare Driver Mutations and Complex Molecular Signatures with Potential Impact for Patient Diagnosis and Prognosis in the Clinic
door: Papaemmanuil, E, et al.
Gepubliceerd in: (2012)

Identification of aberrant splicing events in myelodysplastic syndrome patients with splicing factor gene mutations
door: Pellagatti, A, et al.
Gepubliceerd in: (2017)

Identification of gene expression-based prognostic markers in the hematopoietic stem cells of patients with myelodysplastic syndromes.
door: Pellagatti, A, et al.
Gepubliceerd in: (2013)

Gene expression profiling in the myelodysplastic syndromes.
door: Pellagatti, A, et al.
Gepubliceerd in: (2005)

Inappropriately low hepcidin levels in patients with myelodysplastic syndrome carrying a somatic mutation of SF3B1
door: Ilaria Ambaglio, et al.
Gepubliceerd in: (2013-03-01)

Genome sequencing in the management of myelodysplastic syndromes and related disorders
door: Mario Cazzola, et al.
Gepubliceerd in: (2024-10-01)

GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR GENE IN MYELODYSPLASTIC SYNDROMES - REPLY
door: Boultwood, J, et al.
Gepubliceerd in: (1991)

COMPREHENSIVE ANALYSIS OF MUTATION STATUS, GENE EXPRESSION PROFILES, BLOOD AND BONE MARROW COUNTS AND OUTCOME IN PATIENTS WITH MYELODYSPLASTIC SYNDROMES
door: Pellagatti, A, et al.
Gepubliceerd in: (2014)

Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia.
door: Boultwood, J, et al.
Gepubliceerd in: (2010)

Expression profiling of CD34+cells in patients with myelodysplastic syndromes: differences between early and advanced cases and analysis of apoptosis-related genes
door: Pellagatti, A, et al.
Gepubliceerd in: (2007)

Comparison and Implications of Mutational Profiles of Myelodysplastic Syndromes, Myeloproliferative Neoplasms, and Myelodysplastic/Myeloproliferative Neoplasms: A Meta-Analysis
door: Ziqi Wan, et al.
Gepubliceerd in: (2020-10-01)

Expression profiling of CD34+cells in patients with myelodysplastic syndromes with and without a del(5q)
door: Pellagatti, A, et al.
Gepubliceerd in: (2005)

Genome-wide analysis of copy number change and loss of heterozygosity in myelodysplastic syndrome with del(5q) using high-density SNP arrays
door: Wang, L, et al.
Gepubliceerd in: (2007)

Examining disease boundaries: Genetics of myelodysplastic/myeloproliferative neoplasms
door: Michael J. Hochman, et al.
Gepubliceerd in: (2021-08-01)

Myelodysplastic and myeloproliferative diseases in children: current concepts
door: Vyas, P
Gepubliceerd in: (2014)