Regulation of MLL1 H3K4 methyltransferase activity by its core components.

Histone H3 Lys4 (H3K4) methylation is a prevalent mark associated with transcription activation. A common feature of several H3K4 methyltransferase complexes is the presence of three structural components (RbBP5, Ash2L and WDR5) and a catalytic subunit containing a SET domain. Here we report the fir...

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Bibliographic Details
Main Authors: Dou, Y, Milne, T, Ruthenburg, A, Lee, S, Lee, J, Verdine, G, Allis, C, Roeder, R
Format: Journal article
Language:English
Published: 2006