Prion-like spreading of Alzheimer's disease within the brain's connectome

The prion hypothesis states that misfolded proteins can act as infectious agents that template the misfolding and aggregation of healthy proteins to transmit a disease. Increasing evidence suggests that pathological proteins in neurodegenerative diseases adopt prion-like mechanisms and spread across...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Fornari, S, Schäfer, A, Jucker, M, Goriely, A, Kuhl, E
Format: Journal article
Veröffentlicht: Royal Society 2019