Universal bispecific antibody for targeting tumor cells for destruction by cytotoxic T cells.

Universal bispecific antibody for targeting tumor cells for destruction by cytotoxic T cells.

Previous studies have demonstrated that bispecific hybrid antibodies produced by cell-cell fusion or chemically conjugated heteroaggregates can direct cytotoxic T lymphocytes to kill target cells for which they have no intrinsic specificity, a phenomenon we call effector cell retargeting (ECR). Thes...

Detaylı Bibliyografya
Asıl Yazarlar:	Gilliland, L, Clark, MR, Waldmann, H
Materyal Türü:	Journal article
Dil:	English
Baskı/Yayın Bilgisi:	1988

Benzer Materyaller

T-cell killing of target cells induced by hybrid antibodies: comparison of two bispecific monoclonal antibodies.
Yazar:: Clark, MR, ve diğerleri
Baskı/Yayın Bilgisi: (1987)

Development of humanized bispecific antibodies reactive with cytotoxic lymphocytes and tumor cells overexpressing the HER2 protooncogene.
Yazar:: Shalaby, MR, ve diğerleri
Baskı/Yayın Bilgisi: (1992)

Oncolytic adenovirus expressing bispecific antibody targets T‐cell cytotoxicity in cancer biopsies
Yazar:: Freedman, J, ve diğerleri
Baskı/Yayın Bilgisi: (2017)

Oncolytic adenovirus expressing bispecific antibody targets T‐cell cytotoxicity in cancer biopsies
Yazar:: Joshua D Freedman, ve diğerleri
Baskı/Yayın Bilgisi: (2017-06-01)

Bispecific antibody-activated T cells enhance NK cell-mediated antibody-dependent cellular cytotoxicity
Yazar:: Zhaoming Wang, ve diğerleri
Baskı/Yayın Bilgisi: (2021-12-01)

THE POTENTIAL OF HYBRID ANTIBODIES SECRETED BY HYBRID-HYBRIDOMAS IN TUMOR-THERAPY
Yazar:: Clark, M, ve diğerleri
Baskı/Yayın Bilgisi: (1987)

The role of calcium in the destruction of target cells by cytotoxic T cells
Yazar:: Allbritton, Nancy L. (Nancy Lynn)
Baskı/Yayın Bilgisi: (2005)

Safety Profiling of Tumor-targeted T Cell–Bispecific Antibodies with Alveolus Lung- and Colon-on-Chip
Yazar:: S. Kerns, ve diğerleri
Baskı/Yayın Bilgisi: (2023-01-01)

Harnessing the cytotoxic granule exocytosis to augment the efficacy of T-cell-engaging bispecific antibody therapy
Yazar:: Mika Casey, ve diğerleri
Baskı/Yayın Bilgisi: (2024-01-01)

697 Tumor-targeted CD28 costimulatory bispecific antibodies enhance T cell activation in solid tumors
Yazar:: Gregory Moore, ve diğerleri
Baskı/Yayın Bilgisi: (2020-11-01)

Bispecific antibody-targeted T-cell therapy for acute myeloid leukemia
Yazar:: Ewa Kubicka, ve diğerleri
Baskı/Yayın Bilgisi: (2022-11-01)

Therapeutic Bispecific T-Cell Engager Antibody Targeting the Transferrin Receptor
Yazar:: Mingpeng Fu, ve diğerleri
Baskı/Yayın Bilgisi: (2019-06-01)

Characterization of a novel bispecific antibody targeting tissue factor-positive tumors with T cell engagement
Yazar:: Zhidi Pan, ve diğerleri
Baskı/Yayın Bilgisi: (2022-04-01)

Development of a bispecific antibody targeting PD-L1 and TIGIT with optimal cytotoxicity
Yazar:: Zhenwei Zhong, ve diğerleri
Baskı/Yayın Bilgisi: (2022-10-01)

Targeting tumor vasculature to improve antitumor activity of T cells armed ex vivo with T cell engaging bispecific antibody
Yazar:: Madelyn Espinosa-Cotton, ve diğerleri
Baskı/Yayın Bilgisi: (2023-03-01)

Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies
Yazar:: S Jordan Kerns, ve diğerleri
Baskı/Yayın Bilgisi: (2021-08-01)

Therapeutic potential of rat monoclonal antibodies: isotype specificity of antibody-dependent cell-mediated cytotoxicity with human lymphocytes.
Yazar:: Hale, G, ve diğerleri
Baskı/Yayın Bilgisi: (1985)

Comparative Analysis of Bispecific Antibody and Streptavidin-Targeted Radioimmunotherapy for B-cell Cancers
Yazar:: Green, Damian J., ve diğerleri
Baskı/Yayın Bilgisi: (2020)

Editorial: Bispecific Antibodies for T-Cell Based Immunotherapy
Yazar:: Brian H. Santich, ve diğerleri
Baskı/Yayın Bilgisi: (2020-12-01)

Hybrid antibodies for therapy.
Yazar:: Clark, M, ve diğerleri
Baskı/Yayın Bilgisi: (1988)

Bispecific, T-Cell-Recruiting Antibodies in B-Cell Malignancies
Yazar:: Margaux Lejeune, ve diğerleri
Baskı/Yayın Bilgisi: (2020-05-01)

Bispecific antibodies in indolent B-cell lymphomas
Yazar:: Vivek S. Radhakrishnan, ve diğerleri
Baskı/Yayın Bilgisi: (2024-01-01)

Targeting T cells with tetravalent bispecific antibodies for the treatment of graft-versus-host disease
Yazar:: Madelyn Espinosa-Cotton, ve diğerleri
Baskı/Yayın Bilgisi: (2025-01-01)

Recent advances of bispecific antibodies in solid tumors
Yazar:: Shengnan Yu, ve diğerleri
Baskı/Yayın Bilgisi: (2017-09-01)

Bispecific T cell engager (BiTE®) antibody constructs can mediate bystander tumor cell killing.
Yazar:: Sandra L Ross, ve diğerleri
Baskı/Yayın Bilgisi: (2017-01-01)

Modulating tumor infiltrating myeloid cells to enhance bispecific antibody-driven T cell infiltration and anti-tumor response
Yazar:: Jeong A. Park, ve diğerleri
Baskı/Yayın Bilgisi: (2021-09-01)

Engineering of dendritic cell bispecific extracellular vesicles for tumor-targeting immunotherapy
Yazar:: Fang Xu, ve diğerleri
Baskı/Yayın Bilgisi: (2023-10-01)

Dual Targeting of Tumor Cells with Bispecific Single-Chain Fv-Immunoliposomes
Yazar:: Katharina Mack, ve diğerleri
Baskı/Yayın Bilgisi: (2012-07-01)

Co-targeting cancer stem-like cells and bulk cancer cells with a bispecific antibody
Yazar:: Shi Hu
Baskı/Yayın Bilgisi: (2017-05-01)

Bispecific antibody targets and therapies in multiple myeloma
Yazar:: Matthew Rees, ve diğerleri
Baskı/Yayın Bilgisi: (2024-10-01)

Dual-target Bridging ELISA for Bispecific Antibodies
Yazar:: Min Pei, ve diğerleri
Baskı/Yayın Bilgisi: (2022-10-01)

T-cell stimulating vaccines empower CD3 bispecific antibody therapy in solid tumors
Yazar:: Jim Middelburg, ve diğerleri
Baskı/Yayın Bilgisi: (2024-01-01)

A novel asymmetrical anti-HER2/CD3 bispecific antibody exhibits potent cytotoxicity for HER2-positive tumor cells
Yazar:: Shengnan Yu, ve diğerleri
Baskı/Yayın Bilgisi: (2019-08-01)

Blocking of cytotoxic T cell function by monoclonal antibodies against the CD45 antigen (T200/leukocyte-common antigen).
Yazar:: Tighe, H, ve diğerleri
Baskı/Yayın Bilgisi: (1987)

Src/lck inhibitor dasatinib reversibly switches off cytokine release and T cell cytotoxicity following stimulation with T cell bispecific antibodies
Yazar:: Christian Klein, ve diğerleri
Baskı/Yayın Bilgisi: (2021-07-01)

698 PD-L1 targeted CD28 costimulatory bispecific antibodies enhance T cell activation in solid tumors
Yazar:: Jing Qi, ve diğerleri
Baskı/Yayın Bilgisi: (2021-11-01)

Engineering a tumor-selective prodrug T-cell engager bispecific antibody for safer immunotherapy
Yazar:: Amelia C. McCue, ve diğerleri
Baskı/Yayın Bilgisi: (2024-12-01)

Overcoming tumor heterogeneity by ex vivo arming of T cells using multiple bispecific antibodies
Yazar:: Nai-Kong V Cheung, ve diğerleri
Baskı/Yayın Bilgisi: (2022-01-01)

A Novel T Cell-Engaging Bispecific Antibody for Treating Mesothelin-Positive Solid Tumors
Yazar:: Aerin Yoon, ve diğerleri
Baskı/Yayın Bilgisi: (2020-03-01)

The potential of hybrid antibodies secreted by hybrid-hybridomas in tumour therapy.
Yazar:: Clark, M, ve diğerleri
Baskı/Yayın Bilgisi: (1988)