Tissue-specific effects of sulfonylureas: lessons from studies of cloned K(ATP) channels.

Sulfonylureas stimulate insulin secretion in type-2 diabetic patients by blocking ATP-sensitive (K(ATP)) potassium channels in the pancreatic beta-cell membrane. This effect is mediated by the binding of the drug to the sulfonylurea receptor (SUR) subunit of the channel. K(ATP) channels are also pre...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Ashcroft, F, Gribble, F
स्वरूप: Journal article
भाषा:English
प्रकाशित: 2000