Tissue-specific effects of sulfonylureas: lessons from studies of cloned K(ATP) channels.
Sulfonylureas stimulate insulin secretion in type-2 diabetic patients by blocking ATP-sensitive (K(ATP)) potassium channels in the pancreatic beta-cell membrane. This effect is mediated by the binding of the drug to the sulfonylurea receptor (SUR) subunit of the channel. K(ATP) channels are also pre...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2000
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