The levosimendan metabolite OR-1896 elicits vasodilation by activating the K(ATP) and BK(Ca) channels in rat isolated arterioles.

1. We characterized the vasoactive effects of OR-1896, the long-lived metabolite of the inodilator levosimendan, in coronary and skeletal muscle microvessels. 2. The effect of OR-1896 on isolated, pressurized (80 mmHg) rat coronary and gracilis muscle arteriole (approximately 150 microm) diameters w...

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Bibliographic Details
Main Authors: Erdei, N, Papp, Z, Pollesello, P, Edes, I, Bagi, Z
Format: Journal article
Language:English
Published: 2006