Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas.

Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas.

Clear-cut inherited Mendelian traits, such as familial adenomatous polyposis or hereditary nonpolyposis colorectal cancer, account for <4% of colorectal cancers. Another 20% of all colorectal cancers are thought to occur in individuals with a significant inherited multifactorial susceptibilit...

Detaylı Bibliyografya
Asıl Yazarlar:	Fearnhead, N, Wilding, J, Winney, B, Tonks, S, Bartlett, S, Bicknell, D, Tomlinson, I, Mortensen, N, Bodmer, W
Materyal Türü:	Journal article
Dil:	English
Baskı/Yayın Bilgisi:	2004

Benzer Materyaller

Rare variant hypothesis for multifactorial inheritance: susceptibility to colorectal adenomas as a model.
Yazar:: Fearnhead, N, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

Common and rare variants in multifactorial susceptibility to common diseases.
Yazar:: Bodmer, W, ve diğerleri
Baskı/Yayın Bilgisi: (2008)

Cyclin D1 rare variants in UK multiple adenoma and early-onset colorectal cancer patients.
Yazar:: Bonilla, C, ve diğerleri
Baskı/Yayın Bilgisi: (2011)

Cyclin D1 rare variants in UK multiple adenoma and early-onset colorectal cancer patients
Yazar:: Bonilla, C, ve diğerleri
Baskı/Yayın Bilgisi: (2015)

Genetics of colorectal cancer: hereditary aspects and overview of colorectal tumorigenesis.
Yazar:: Fearnhead, N, ve diğerleri
Baskı/Yayın Bilgisi: (2002)

Genetic Variants Associated with Colorectal Adenoma Susceptibility.
Yazar:: Anna Abulí, ve diğerleri
Baskı/Yayın Bilgisi: (2016-01-01)

Targeted killing of colorectal cell lines and murine adenomas using a monoclonal antibody against membrane bound carcinoembryonic antigen
Yazar:: Conaghan, P, ve diğerleri
Baskı/Yayın Bilgisi: (2006)

Inherited susceptibility to colorectal adenomas and carcinomas: evidence for a new predisposition gene on 15q14-q22.
Yazar:: Tomlinson, I, ve diğerleri
Baskı/Yayın Bilgisi: (1999)

The HLA system and the analysis of multifactorial genetic disease.
Yazar:: Tomlinson, I, ve diğerleri
Baskı/Yayın Bilgisi: (1995)

Role of rare variants in undetermined multiple adenomatous polyposis and early-onset colorectal cancer.
Yazar:: Lefevre, J, ve diğerleri
Baskı/Yayın Bilgisi: (2012)

Role of rare variants in undetermined multiple adenomatous polyposis and early-onset colorectal cancer
Yazar:: Lefevre, J, ve diğerleri
Baskı/Yayın Bilgisi: (2012)

Mutations in the AXIN1 gene in advanced prostate cancer.
Yazar:: Yardy, G, ve diğerleri
Baskı/Yayın Bilgisi: (2009)

Frequency of germline hereditary non-polyposis colorectal cancer gene mutations in patients with multiple or early onset colorectal adenomas.
Yazar:: Beck, N, ve diğerleri
Baskı/Yayın Bilgisi: (1997)

Educational Case: Genetic Mutations and Multifactorial Inheritance
Yazar:: Eric S. Suarez MD, ve diğerleri
Baskı/Yayın Bilgisi: (2017-08-01)

Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fission.
Yazar:: Preston, S, ve diğerleri
Baskı/Yayın Bilgisi: (2003)

European camparison populations needed, can you help?
Yazar:: Tonks, S, ve diğerleri
Baskı/Yayın Bilgisi: (2007)

A SNP approach to HLA typing analysis
Yazar:: Evseeva, I, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

Multiple abnormalities in a foetus: a possibility of multifactorial inheritance disorder
Yazar:: D N Sinha
Baskı/Yayın Bilgisi: (2016-01-01)

Targeted killing of colorectal cancer cell lines by a humanised IgG1 monoclonal antibody that binds to membrane-bound carcinoembryonic antigen.
Yazar:: Conaghan, P, ve diğerleri
Baskı/Yayın Bilgisi: (2008)

Germline mutations in the mismatch repair genes hMLH1 and hMSH2 may predispose to the formation of multiple adenomatous polyps
Yazar:: Fearnhead, N, ve diğerleri
Baskı/Yayın Bilgisi: (2002)

Ceramide signalling in inherited and multifactorial brain metabolic diseases
Yazar:: Devesh C. Pant, ve diğerleri
Baskı/Yayın Bilgisi: (2020-09-01)

The diversity of mitochondrial sequences in Eurasia
Yazar:: Tonks, S, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

Mechanisms of loss of HLA class I expression on colorectal tumor cells.
Yazar:: Browning, M, ve diğerleri
Baskı/Yayın Bilgisi: (1996)

Genetic susceptibility to multifactorial diseases.
Yazar:: Hill, A
Baskı/Yayın Bilgisi: (1997)

APC mutations are sufficient for the growth of early colorectal adenomas.
Yazar:: Lamlum, H, ve diğerleri
Baskı/Yayın Bilgisi: (2000)

Top down or bottom up morphogenesis of colorectal adenomas: Competing management structures in the origins of colorectal neoplasia
Yazar:: Preston, S, ve diğerleri
Baskı/Yayın Bilgisi: (2003)

Germline APC variants in patients with multiple colorectal adenomas, with evidence for the particular importance of E1317Q.
Yazar:: Lamlum, H, ve diğerleri
Baskı/Yayın Bilgisi: (2000)

A common mtDNA variant may be a susceptibility factor in 3 multifactorial diseases.
Yazar:: Poulton, J, ve diğerleri
Baskı/Yayın Bilgisi: (2001)

Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.
Yazar:: Carvajal-Carmona, L, ve diğerleri
Baskı/Yayın Bilgisi: (2013)

Criteria for choosing non-patient control groups in genetically based case-control studies in the United Kingdom. People of the British Isles: the pilot project
Yazar:: Evseeva, I, ve diğerleri
Baskı/Yayın Bilgisi: (2007)

Direct and immune mediated antibody targeting of ERBB receptors in a colorectal cancer cell-line panel.
Yazar:: Ashraf, S, ve diğerleri
Baskı/Yayın Bilgisi: (2012)

Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines.
Yazar:: Wong, N, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma.
Yazar:: Lipton, L, ve diğerleri
Baskı/Yayın Bilgisi: (2003)

Germline HNPCC gene variants have little influence on the risk for sporadic colorectal cancer.
Yazar:: Tomlinson, I, ve diğerleri
Baskı/Yayın Bilgisi: (1997)

Etiology and familial inheritance of pleomorphic adenomas
Yazar:: Krysten Clark
Baskı/Yayın Bilgisi: (2017-06-01)

The influence of modifier genes on the disease phenotype in South African families with hereditary nonpolyposis colorectal cancer (HNPCC).
Yazar:: Felix, R, ve diğerleri
Baskı/Yayın Bilgisi: (2003)

Top-down or bottom-up morphogenesis of colorectal adenomas: Competing management structures in the origins of colonic neoplasia
Yazar:: Preston, S, ve diğerleri
Baskı/Yayın Bilgisi: (2003)

Polygenic inheritance, GWAS, polygenic risk scores, and the search for functional variants
Yazar:: Crouch, DJM, ve diğerleri
Baskı/Yayın Bilgisi: (2020)

Rare genetic variants and the risk of cancer.
Yazar:: Bodmer, W, ve diğerleri
Baskı/Yayın Bilgisi: (2010)

CDX2 mutations do not account for juvenile polyposis or Peutz-Jeghers syndrome and occur infrequently in sporadic colorectal cancers.
Yazar:: Woodford-Richens, K, ve diğerleri
Baskı/Yayın Bilgisi: (2001)