PIP2-binding site in Kir channels: definition by multiscale biomolecular simulations
Phosphatidylinositol bisphosphate (PIP₂) is an activator of mammalian inwardly rectifying potassium (Kir) channels. Multiscale simulations, via a sequential combination of coarse-grained and atomistic molecular dynamics, enabled exploration of the interactions of PIP₂ molecules within the inner leaf...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Chemical Society
2009
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| Subjects: |