CBP/p300 bromodomains regulate amyloid-like protein aggregation upon aberrant lysine acetylation

Lysine acetylation is becoming increasingly recognized as a general biological principle in cellular homeostasis, and is subject to abnormal control in different human pathologies. Here, we describe a global effect on amyloid-like protein aggregation in human cells that results from aberrant lysine...

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Autori principali: Olzscha, H, Fedorov, O, Kessler, B, Knapp, S, La Thangue, N
Natura: Journal article
Lingua:English
Pubblicazione: Cell Press 2016