Study protocol for a randomised controlled double-blinded trial of the dose-dependent efficacy and safety of primaquine for clearance of gametocytes in children with uncomplicated falciparum malaria in Uganda

Study protocol for a randomised controlled double-blinded trial of the dose-dependent efficacy and safety of primaquine for clearance of gametocytes in children with uncomplicated falciparum malaria in Uganda

Objectives: For the purpose of blocking transmission of Plasmodium falciparum malaria from humans to mosquitoes, a single dose of primaquine is recommended by theWHO as an addition to artemisinin combination therapy. Primaquine clears gametocytes but causes dose-dependent haemolysis in individuals w...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Eziefula, A, Staedke, S, Yeung, S, Webb, E, Kamya, M, White, N, Bousema, T, Drakeley, C
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	BMJ Publishing Group 2013

Ижил төстэй зүйлс

Single dose primaquine for clearance of Plasmodium falciparum gametocytes in children with uncomplicated malaria in Uganda: A randomised, controlled, double-blind, dose-ranging trial
-н: Eziefula, A, зэрэг
Хэвлэсэн: (2014)

Single dose primaquine for clearance of Plasmodium falciparum gametocytes in children with uncomplicated malaria in Uganda: a randomised, controlled, double-blind, dose-ranging trial.
-н: Eziefula, A, зэрэг
Хэвлэсэн: (2014)

Single dose primaquine for clearance of Plasmodium falaparum gametocytes in children with uncomplicated malaria in Uganda: a randomised, controlled, double-blind, dose-ranging trial
-н: Eziefula, A, зэрэг
Хэвлэсэн: (2014)

Risk factors for gametocyte carriage in uncomplicated falciparum malaria.
-н: Price, R, зэрэг
Хэвлэсэн: (1999)

Gametocyte clearance dynamics following oral artesunate treatment of uncomplicated falciparum malaria in Malian children
-н: Djimde Abdoulaye A., зэрэг
Хэвлэсэн: (2016-01-01)

Effects of liver-stage clearance by Primaquine on gametocyte carriage of Plasmodium vivax and P. falciparum.
-н: Rahel Wampfler, зэрэг
Хэвлэсэн: (2017-07-01)

Primaquine clears submicroscopic Plasmodium falciparum gametocytes that persist after treatment with sulphadoxine-pyrimethamine and artesunate.
-н: Seif Shekalaghe, зэрэг
Хэвлэсэн: (2007-10-01)

Optimal timing of primaquine to reduce Plasmodium falciparum gametocyte carriage when co-administered with artemether–lumefantrine
-н: Seif Shekalaghe, зэрэг
Хэвлэсэн: (2020-01-01)

Comparative effect of artemether-lumefantrine and artesunate-amodiaquine on gametocyte clearance in children with uncomplicated Plasmodium falciparum malaria in Madagascar
-н: Malalanandrianina A. Rakotoarisoa, зэрэг
Хэвлэсэн: (2022-11-01)

Rationale for short course primaquine in Africa to interrupt malaria transmission
-н: Eziefula Alice C, зэрэг
Хэвлэсэн: (2012-10-01)

Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity.
-н: Stepniewska, K, зэрэг
Хэвлэсэн: (2008)

Effects of chloroquine and sulfadoxine/pyrimethamine on gametocytes in patients with uncomplicated Plasmodium falciparum malaria in Colombia
-н: Lyda Osorio, зэрэг
Хэвлэсэн: (2002-12-01)

Differential infectivity of gametocytes after artemisinin-based combination therapy of uncomplicated falciparum malaria
-н: Dinkorma T. Ouologuem, зэрэг
Хэвлэсэн: (2018-12-01)

Effectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trial.
-н: Smithuis, F, зэрэг
Хэвлэсэн: (2010)

Primaquine to prevent transmission of falciparum malaria.
-н: White, N
Хэвлэсэн: (2013)

Primaquine to prevent transmission of falciparum malaria
-н: White, N
Хэвлэсэн: (2013)

Primaquine to prevent transmission of falciparum malaria.
-н: White, N
Хэвлэсэн: (2013)

<it>Plasmodium falciparum </it>gametocyte dynamics in areas of different malaria endemicity
-н: von Seidlein Lorenz, зэрэг
Хэвлэсэн: (2008-12-01)

Antibody responses to crude gametocyte extract predict plasmodium falciparum gametocyte carriage in Kenya
-н: Omondi, BR, зэрэг
Хэвлэсэн: (2020)

Editorial commentary: single-dose primaquine as gametocytocidal treatment in patients with uncomplicated falciparum malaria.
-н: Dondorp, A
Хэвлэсэн: (2013)

Efficacy of single dose primaquine with artemisinin combination therapy on P. falciparum gametocytes and transmission: A WWARN individual patient meta-analysis
-н: Stepniewska, K, зэрэг
Хэвлэсэн: (2020)

Gametocyte carriage after seasonal malaria chemoprevention in Plasmodium falciparum infected asymptomatic children
-н: Abdullahi Ahmad, зэрэг
Хэвлэсэн: (2021-03-01)

Antibody Responses to Crude Gametocyte Extract Predict Plasmodium falciparum Gametocyte Carriage in Kenya
-н: Brian R. Omondi, зэрэг
Хэвлэсэн: (2021-02-01)

Effects of antifolates - co-trimoxazole and pyrimethamine-sulfadoxine - on gametocytes in children with acute, symptomatic, uncomplicated, Plasmodium falciparum malaria
-н: A Sowunmi, зэрэг
Хэвлэсэн: (2005-07-01)

Factors contributing to delay in parasite clearance in uncomplicated falciparum malaria in children
-н: Sijuade Abayomi, зэрэг
Хэвлэсэн: (2010-02-01)

Anti-gametocyte antigen humoral immunity and gametocytemia during treatment of uncomplicated falciparum malaria: a multi-national study
-н: O'Flaherty, K, зэрэг
Хэвлэсэн: (2022)

Anti-Gametocyte Antigen Humoral Immunity and Gametocytemia During Treatment of Uncomplicated Falciparum Malaria: A Multi-National Study
-н: Katherine O’Flaherty, зэрэг
Хэвлэсэн: (2022-04-01)

Population pharmacokinetics of quinine in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda.
-н: Kloprogge, F, зэрэг
Хэвлэсэн: (2014)

Revisiting the circulation time of <it>Plasmodium falciparum </it>gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs
-н: Sawa Patrick, зэрэг
Хэвлэсэн: (2010-05-01)

Plasmodium falciparum gametocyte carriage in longitudinally monitored incident infections is associated with duration of infection and human host factors
-н: Chiara Andolina, зэрэг
Хэвлэсэн: (2023-05-01)

Ethics, Economics, and the Use of Primaquine to Reduce Falciparum Malaria Transmission in Asymptomatic Populations
-н: Lubell, Y, зэрэг
Хэвлэсэн: (2014)

Nonlinear mixed effects modeling of gametocyte carriage in patients with uncomplicated malaria
-н: Little Francesca, зэрэг
Хэвлэсэн: (2010-02-01)

<it>Plasmodium falciparum </it>gametocyte carriage in asymptomatic children in western Kenya
-н: Akim Ikupa NJ, зэрэг
Хэвлэсэн: (2004-06-01)

Predicting mosquito infection from Plasmodium falciparum gametocyte density and estimating the reservoir of infection
-н: Thomas S Churcher, зэрэг
Хэвлэсэн: (2013-05-01)

Primaquine to reduce transmission of Plasmodium falciparum malaria in Mali: a single-blind, dose-ranging, adaptive randomised phase 2 trial
-н: Dicko, A, зэрэг
Хэвлэсэн: (2016)

Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: A systematic review and meta-analysis of individual patient data
-н: Abdulla, S, зэрэг
Хэвлэсэн: (2016)

Gametocyte carriage in uncomplicated plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data
-н: Abdulla, S, зэрэг
Хэвлэсэн: (2016)

Single dose primaquine to reduce gametocyte carriage and Plasmodium falciparum transmission in Cambodia: An open-label randomized trial.
-н: Jessica T Lin, зэрэг
Хэвлэсэн: (2017-01-01)

Population Pharmacokinetics of Lumefantrine in Pregnant and Nonpregnant Women With Uncomplicated Plasmodium falciparum Malaria in Uganda.
-н: Kloprogge, F, зэрэг
Хэвлэсэн: (2013)

Population pharmacokinetics of Artemether and dihydroartemisinin in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda.
-н: Tarning, J, зэрэг
Хэвлэсэн: (2012)