Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice.

AIMS/HYPOTHESIS: We examined the time-dependent effects of deletion of the gene encoding protein kinase C epsilon (Prkce) on glucose homeostasis, insulin secretion and hepatic lipid metabolism in fat-fed mice. METHODS: Prkce(-/-) and wild-type (WT) mice were fed a high-fat diet for 1 to 16 weeks an...

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Bibliographic Details
Main Authors: Raddatz, K, Turner, N, Frangioudakis, G, Liao, B, Pedersen, D, Cantley, J, Wilks, D, Preston, E, Hegarty, B, Leitges, M, Raftery, M, Biden, T, Schmitz-Peiffer, C
Format: Journal article
Language:English
Published: 2011