Sensing of mycobacterial arabinogalactan by galectin-9 exacerbates mycobacterial infection

Mycobacterial arabinogalactan (AG) is an essential cell wall component of mycobacteria and a frequent structural and bio-synthetical target for anti-tuberculosis (TB) drug development. Here, we report that mycobacterial AG is recognized by galectin-9 and exacerbates mycobacterial infection. Administ...

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Main Authors: Wu, X, Wu, Y, Zheng, R, Tang, F, Qin, L, Lai, D, Zhang, L, Chen, L, Yan, B, Yang, H, Wang, Y, Li, F, Zhang, J, Wang, F, Wang, L, Cao, Y, Ma, M, Liu, Z, Chen, J, Huang, X, Wang, J, Jin, R, Wang, P, Sun, Q, Sha, W, Lyu, L, Moura Alves, P, Dorhoi, A, Pei, G, Zhang, P, Gao, S, Randow, F, Zeng, G, Chen, C, Ye, X-S, Kaufmann, S, Liu, H, Ge, B
Format: Journal article
Language:English
Published: EMBO Press 2021