Are polygenic risk scores for systolic blood pressure and LDL-cholesterol associated with treatment effectiveness, and clinical outcomes among those on treatment?

Aims  Many studies have investigated associations between polygenic risk scores (PRS) and the incidence of cardiovascular disease (CVD); few have examined whether risk factor-related PRS predict CVD outcomes among adults treated with risk-modifying therapies. We assessed whether PRS for systolic blo...

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Bibliographic Details
Main Authors: Tapela, NM, Collister, J, Liu, X, Clifton, L, Stiby, A, Murgia, F, Hopewell, JC, Hunter, DJ
Format: Journal article
Language:English
Published: Oxford University Press 2021