A complex barcode underlies the heterogeneous response of p53 to stress.
The tumour suppressor p53 is activated following stress and initiates a heterogeneous response in a cell-, tissue- and stress-dependent manner. This heterogeneity is reflected in the different physiological outcomes that follow p53 activation. One mechanism that may contribute to this variability is...
| Main Authors: | , , |
|---|---|
| 格式: | Journal article |
| 語言: | English |
| 出版: |
2008
|
| _version_ | 1826289847474585600 |
|---|---|
| author | Murray-Zmijewski, F Slee, E Lu, X |
| author_facet | Murray-Zmijewski, F Slee, E Lu, X |
| author_sort | Murray-Zmijewski, F |
| collection | OXFORD |
| description | The tumour suppressor p53 is activated following stress and initiates a heterogeneous response in a cell-, tissue- and stress-dependent manner. This heterogeneity is reflected in the different physiological outcomes that follow p53 activation. One mechanism that may contribute to this variability is the promoter selectivity of p53 target genes. p53 is at the hub of numerous signalling pathways that are triggered in response to particular stresses, all of which can leave their mark on p53 by way of post-translational modifications and interactions with cofactors. The precise combination of these marks, much like the bars in a barcode, dictates the behaviour of p53 in any given situation. |
| first_indexed | 2024-03-07T02:35:09Z |
| format | Journal article |
| id | oxford-uuid:a8879030-1821-4fe4-b49e-193ab79c1250 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:35:09Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:a8879030-1821-4fe4-b49e-193ab79c12502022-03-27T03:02:12ZA complex barcode underlies the heterogeneous response of p53 to stress.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a8879030-1821-4fe4-b49e-193ab79c1250EnglishSymplectic Elements at Oxford2008Murray-Zmijewski, FSlee, ELu, XThe tumour suppressor p53 is activated following stress and initiates a heterogeneous response in a cell-, tissue- and stress-dependent manner. This heterogeneity is reflected in the different physiological outcomes that follow p53 activation. One mechanism that may contribute to this variability is the promoter selectivity of p53 target genes. p53 is at the hub of numerous signalling pathways that are triggered in response to particular stresses, all of which can leave their mark on p53 by way of post-translational modifications and interactions with cofactors. The precise combination of these marks, much like the bars in a barcode, dictates the behaviour of p53 in any given situation. |
| spellingShingle | Murray-Zmijewski, F Slee, E Lu, X A complex barcode underlies the heterogeneous response of p53 to stress. |
| title | A complex barcode underlies the heterogeneous response of p53 to stress. |
| title_full | A complex barcode underlies the heterogeneous response of p53 to stress. |
| title_fullStr | A complex barcode underlies the heterogeneous response of p53 to stress. |
| title_full_unstemmed | A complex barcode underlies the heterogeneous response of p53 to stress. |
| title_short | A complex barcode underlies the heterogeneous response of p53 to stress. |
| title_sort | complex barcode underlies the heterogeneous response of p53 to stress |
| work_keys_str_mv | AT murrayzmijewskif acomplexbarcodeunderliestheheterogeneousresponseofp53tostress AT sleee acomplexbarcodeunderliestheheterogeneousresponseofp53tostress AT lux acomplexbarcodeunderliestheheterogeneousresponseofp53tostress AT murrayzmijewskif complexbarcodeunderliestheheterogeneousresponseofp53tostress AT sleee complexbarcodeunderliestheheterogeneousresponseofp53tostress AT lux complexbarcodeunderliestheheterogeneousresponseofp53tostress |