Solubilized pancreatic extracellular matrix from juvenile pigs protects isolated human islets from hypoxia-induced damage: a viable option for clinical islet transplantation

Solubilized pancreatic extracellular matrix from juvenile pigs protects isolated human islets from hypoxia-induced damage: a viable option for clinical islet transplantation

The pancreatic extracellular matrix (ECM) is an enormously complex construct. Previous studies underline the challenges to identify the optimal combinations and ratios of individual ECM proteins for promoting survival and function of isolated and transplanted islets. This study aimed on assessing th...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Brandhorst, H, Krishtul, S, Brandhorst, D, Baruch, L, Machluf, M, Johnson, PRV
التنسيق:	Journal article
اللغة:	English
منشور في:	Hindawi Publishing Corporation 2023

مواد مشابهة

Pancreatic islets: methods for isolation and purification of juvenile and adult pig islets
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Pig pancreas oxygenation at 20 degrees C increases islet ATP generation but deteriorates islet function.
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Activation of NFκB dependent apoptotic pathway in pancreatic islet cells by hypoxia.
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Long-term preservation of the pig pancreas by a one-layer method for successful islet isolation.
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Induction and amelioration of environmental stress in isolated islets until transplantation
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Can the density of native pancreatic tissue slices predict human islet isolation and purification outcome?
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Effect of etanercept concentration on human islet integrity
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Successful pancreas preservation by a perfluorocarbon-based one-layer method for subsequent pig islet isolation.
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High Seeding Density Induces Local Hypoxia and Triggers a Proinflammatory Response in Isolated Human Islets
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Hyperthermic Preconditioning Protects Pig Islet Grafts from Early Inflammation but Enhances Rejection in Immunocompetent Mice
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High-dosed nicotinamide decreases early graft failure after pig to nude rat intraportal islet transplantation.
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Quantifying the effects of different neutral proteases on human islet integrity
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Effect of stable glutamine compounds on porcine islet culture.
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Degraded collagenase deteriorates islet viability.
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Influence of collagenase loading on long-term preservation of pig pancreas by the two-layer method for subsequent islet isolation.
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Does islet size really influence graft function following clinical islet transplantation?
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Timing of hyperthermic preconditioning affects islet resistance against inflammation.
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Influence of neutral protease activity on human islet isolation outcome.
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