Solubilized pancreatic extracellular matrix from juvenile pigs protects isolated human islets from hypoxia-induced damage: a viable option for clinical islet transplantation

Solubilized pancreatic extracellular matrix from juvenile pigs protects isolated human islets from hypoxia-induced damage: a viable option for clinical islet transplantation

The pancreatic extracellular matrix (ECM) is an enormously complex construct. Previous studies underline the challenges to identify the optimal combinations and ratios of individual ECM proteins for promoting survival and function of isolated and transplanted islets. This study aimed on assessing th...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Brandhorst, H, Krishtul, S, Brandhorst, D, Baruch, L, Machluf, M, Johnson, PRV
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	Hindawi Publishing Corporation 2023

Παρόμοια τεκμήρια

Pancreatic islets: methods for isolation and purification of juvenile and adult pig islets
ανά: Brandhorst, H, κ.ά.
Έκδοση: (2016)

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ανά: Brandhorst, D, κ.ά.
Έκδοση: (2021)

The ischaemic preconditioning paradox and its implications for islet isolation from heart-beating and non heart-beating donors
ανά: Brandhorst, D, κ.ά.
Έκδοση: (2022)

Pig Pancreas Oxygenation at 20°C Increases Islet ATP Generation but Deteriorates Islet Function
ανά: M. Iken, κ.ά.
Έκδοση: (2009-07-01)

High concentrations of Etanercept reduce human islet function and integrity
ανά: Brandhorst, D, κ.ά.
Έκδοση: (2021)

High Concentrations of Etanercept Reduce Human Islet Function and Integrity
ανά: Brandhorst D, κ.ά.
Έκδοση: (2021-02-01)

Pig pancreas oxygenation at 20 degrees C increases islet ATP generation but deteriorates islet function.
ανά: Iken, M, κ.ά.
Έκδοση: (2009)

Pretransplant induction of HSP-70 in isolated adult pig islets decreases early islet xenograft survival.
ανά: Brandhorst, D, κ.ά.
Έκδοση: (2000)

Pancreatic L-Glutamine Administration Protects Pig Islets from Cold Ischemic Injury and Increases Resistance toward Inflammatory Mediators
ανά: Brandhorst, H, κ.ά.
Έκδοση: (2016)

Pancreatic L-Glutamine Administration Protects Pig Islets from Cold Ischemic Injury and Increases Resistance toward Inflammatory Mediators
ανά: Heide Brandhorst, κ.ά.
Έκδοση: (2016-03-01)

Pretransplant Induction of HSP-70 in Isolated Adult Pig Islets Decreases Early Islet Xenograft Survival
ανά: Daniel Brandhorst Ph.D., κ.ά.
Έκδοση: (2000-05-01)

Heat-exposed pig islets are protected from inflammatory mediators but express proapoptotic proteins.
ανά: Brandhorst, D, κ.ά.
Έκδοση: (2003)

Prevention of early islet graft failure by selective inducible nitric oxide synthase inhibitors after pig to nude rat intraportal islet transplantation.
ανά: Brandhorst, D, κ.ά.
Έκδοση: (2001)

Ischaemia is linked to inflammation and induction of angiogenesis in pancreatic islets.
ανά: Linn, T, κ.ά.
Έκδοση: (2006)

Strategies to improve the oxygen supply to microencapsulated islets
ανά: Brandhorst, D, κ.ά.
Έκδοση: (2019)

Activation of NFκB dependent apoptotic pathway in pancreatic islet cells by hypoxia.
ανά: Lai, Y, κ.ά.
Έκδοση: (2009)

High seeding density induces local hypoxia and triggers a proinflammatory response in isolated human islets
ανά: Brandhorst, D, κ.ά.
Έκδοση: (2016)

Hypoxia-induced damage in human islets is reduced with the use of mesenchymal stem cell-preconditioned medium
ανά: Brandhorst, D, κ.ά.
Έκδοση: (2017)

Adaption of neutral protease activity for islet isolation from the long-term two-layer method-stored pig pancreas.
ανά: Brandhorst, D, κ.ά.
Έκδοση: (2005)

Hyperthermic preconditioning protects pig islet grafts from early inflammation but enhances rejection in immunocompetent mice.
ανά: Brandhorst, D, κ.ά.
Έκδοση: (2003)

Long-term preservation of the pig pancreas by a one-layer method for successful islet isolation.
ανά: Brandhorst, D, κ.ά.
Έκδοση: (2005)

Induction and amelioration of environmental stress in isolated islets until transplantation
ανά: Brandhorst, D, κ.ά.
Έκδοση: (2006)

Proteomic profiling reveals the ambivalent character of the mesenchymal stem cell secretome: assessing the effect of preconditioned media on isolated human islets
ανά: Brandhorst, H, κ.ά.
Έκδοση: (2020)

Expression of complement regulatory proteins on islets of Langerhans: a comparison between human islets and islets isolated from normal and hDAF transgenic pigs.
ανά: Bennet, W, κ.ά.
Έκδοση: (2001)

Can the density of native pancreatic tissue slices predict human islet isolation and purification outcome?
ανά: Eckhard, M, κ.ά.
Έκδοση: (2004)

Effect of etanercept concentration on human islet integrity
ανά: Acreman, S, κ.ά.
Έκδοση: (2017)

Successful pancreas preservation by a perfluorocarbon-based one-layer method for subsequent pig islet isolation.
ανά: Brandhorst, D, κ.ά.
Έκδοση: (2005)

High Seeding Density Induces Local Hypoxia and Triggers a Proinflammatory Response in Isolated Human Islets
ανά: Daniel Brandhorst, κ.ά.
Έκδοση: (2016-08-01)

Hyperthermic Preconditioning Protects Pig Islet Grafts from Early Inflammation but Enhances Rejection in Immunocompetent Mice
ανά: Daniel Brandhorst Ph.D., κ.ά.
Έκδοση: (2003-11-01)

High-dosed nicotinamide decreases early graft failure after pig to nude rat intraportal islet transplantation.
ανά: Brandhorst, D, κ.ά.
Έκδοση: (2002)

Prevention of intraportal islet failure by a highly selective iNOS inhibitor in the pig-to-nude rat model.
ανά: Brandhorst, D, κ.ά.
Έκδοση: (2001)

Enzyme development for human islet isolation: Five decades of progress or stagnation?
ανά: Brandhorst, D, κ.ά.
Έκδοση: (2017)

Pancreas storage in oxygenated perfluorodecalin does not restore post-transplant function of isolated pig islets pre-damaged by warm ischemia.
ανά: Brandhorst, D, κ.ά.
Έκδοση: (2006)

Quantifying the effects of different neutral proteases on human islet integrity
ανά: Brandhorst, H, κ.ά.
Έκδοση: (2018)

Effect of stable glutamine compounds on porcine islet culture.
ανά: Brandhorst, H, κ.ά.
Έκδοση: (2005)

Degraded collagenase deteriorates islet viability.
ανά: Brandhorst, H, κ.ά.
Έκδοση: (2008)

Influence of collagenase loading on long-term preservation of pig pancreas by the two-layer method for subsequent islet isolation.
ανά: Brandhorst, D, κ.ά.
Έκδοση: (2005)

Does islet size really influence graft function following clinical islet transplantation?
ανά: Hughes, S, κ.ά.
Έκδοση: (2018)

Timing of hyperthermic preconditioning affects islet resistance against inflammation.
ανά: Brandhorst, D, κ.ά.
Έκδοση: (2005)

Influence of neutral protease activity on human islet isolation outcome.
ανά: Brandhorst, H, κ.ά.
Έκδοση: (2005)