Anti-TNF therapy, from rationale to standard of care: what lessons has it taught us?
In the mid-1980s, new molecular tools enabled the biology of cytokine expression and regulation to be studied. Our group uncovered a TNF-dependent cascade in active rheumatoid synovium, suggesting that TNF might be a therapeutic target; this concept was supported in an animal model of the disease. T...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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