Total synthesis of (±)-streptonigrin: de novo construction of a pentasubstituted pyridine using ring-closing metathesis.

The synthesis of the potent antitumor agent (±)-streptonigrin has been achieved in 14 linear steps and 11% overall yield from ethyl glyoxalate. The synthesis features a challenging ring-closing metathesis reaction, followed by elimination and aromatization, to furnish a key pentasubstituted pyridine...

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Bibliografiske detaljer
Main Authors: Donohoe, T, Jones, C, Barbosa, L
Format: Journal article
Sprog:English
Udgivet: 2011