Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women.

The CYP19A1 gene encodes the enzyme aromatase, which is responsible for the final step in the biosynthesis of estrogens. In this study, we used a systematic two-step approach that included gene resequencing and a haplotype-based analysis to comprehensively survey common genetic variation across the...

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Detalhes bibliográficos
Principais autores:	Haiman, C, Dossus, L, Setiawan, V, Stram, DO, Dunning, A, Thomas, G, Thun, M, Albanes, D, Altshuler, D, Ardanaz, E, Boeing, H, Buring, J, Burtt, N, Calle, E, Chanock, S, Clavel-Chapelon, F, Colditz, G, Cox, D, Feigelson, H, Hankinson, SE, Hayes, R, Henderson, B, Hirschhorn, J, Hoover, R, Hunter, D
Formato:	Journal article
Idioma:	English
Publicado em:	2007

Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women.

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