Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women.

Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women.

The CYP19A1 gene encodes the enzyme aromatase, which is responsible for the final step in the biosynthesis of estrogens. In this study, we used a systematic two-step approach that included gene resequencing and a haplotype-based analysis to comprehensively survey common genetic variation across the...

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Bibliographic Details
Main Authors: Haiman, C, Dossus, L, Setiawan, V, Stram, DO, Dunning, A, Thomas, G, Thun, M, Albanes, D, Altshuler, D, Ardanaz, E, Boeing, H, Buring, J, Burtt, N, Calle, E, Chanock, S, Clavel-Chapelon, F, Colditz, G, Cox, D, Feigelson, H, Hankinson, SE, Hayes, R, Henderson, B, Hirschhorn, J, Hoover, R, Hunter, D
Format: Journal article
Language:English
Published: 2007

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