Use of cell-penetrating-peptides in oligonucleotide splice switching therapy.

Use of cell-penetrating-peptides in oligonucleotide splice switching therapy.

The hydrophobic plasma membrane constitutes an indispensable barrier for cells, allowing influx of essential molecules while preventing access to other macromolecules. Although pivotal for the maintenance of cells, the inability to cross the plasma membrane is one of the major obstacles toward curre...

Bibliográfalaš dieđut
Váldodahkkit:	El Andaloussi, SA, Hammond, S, Mäger, I, Wood, M
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	2012

Geahča maid

Design and application of bispecific splice-switching oligonucleotides.
Dahkki: Bestas, B, et al.
Almmustuhtton: (2014)

Cell-penetrating peptides-based strategies for the delivery of splice redirecting antisense oligonucleotides.
Dahkki: Andaloussi, S, et al.
Almmustuhtton: (2011)

Lipophilic Peptide Dendrimers for Delivery of Splice-Switching Oligonucleotides
Dahkki: Haneen Daralnakhla, et al.
Almmustuhtton: (2021-01-01)

Insights into the cellular trafficking of splice redirecting oligonucleotides complexed with chemically modified cell-penetrating peptides.
Dahkki: Hassane, F, et al.
Almmustuhtton: (2011)

Cell penetrating peptide delivery of splice directing oligonucleotides as a treatment for Duchenne muscular dystrophy.
Dahkki: Betts, C, et al.
Almmustuhtton: (2013)

Novel Orthogonally Hydrocarbon-Modified Cell-Penetrating Peptide Nanoparticles Mediate Efficient Delivery of Splice-Switching Antisense Oligonucleotides In Vitro and In Vivo
Dahkki: Safa Bazaz, et al.
Almmustuhtton: (2021-08-01)

Induction of splice correction by cell-penetrating peptide nucleic acids.
Dahkki: El-Andaloussi, S, et al.
Almmustuhtton: (2006)

Scavenger receptor-mediated uptake of cell-penetrating peptide nanocomplexes with oligonucleotides.
Dahkki: Ezzat, K, et al.
Almmustuhtton: (2012)

Evaluation of cell-penetrating peptide delivery of antisense oligonucleotides for therapeutic efficacy in spinal muscular atrophy
Dahkki: Hammond, S, et al.
Almmustuhtton: (2019)

Fine tuning of phosphorothioate inclusion in 2'-O-methyl oligonucleotides contributes to specific cell targeting for splice-switching modulation
Dahkki: Aoki, Y, et al.
Almmustuhtton: (2021)

Splice-switching efficiency and specificity for oligonucleotides with locked nucleic acid monomers.
Dahkki: Guterstam, P, et al.
Almmustuhtton: (2008)

Immortalized canine dystrophic myoblast cell lines for development of peptide-conjugated splice-switching oligonucleotides
Dahkki: Tone, Y, et al.
Almmustuhtton: (2021)

Fine Tuning of Phosphorothioate Inclusion in 2′-O-Methyl Oligonucleotides Contributes to Specific Cell Targeting for Splice-Switching Modulation
Dahkki: Yoshitsugu Aoki, et al.
Almmustuhtton: (2021-10-01)

PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation.
Dahkki: Ezzat, K, et al.
Almmustuhtton: (2011)

Intravitreal Injection of Splice-switching Oligonucleotides to Manipulate Splicing in Retinal Cells
Dahkki: Xavier Gérard, et al.
Almmustuhtton: (2015-01-01)

Correlating In Vitro Splice Switching Activity With Systemic In Vivo Delivery Using Novel ZEN-modified Oligonucleotides
Dahkki: Suzan M Hammond, et al.
Almmustuhtton: (2014-01-01)

Cellular internalization kinetics of (luciferin-)cell-penetrating peptide conjugates.
Dahkki: Eiríksdóttir, E, et al.
Almmustuhtton: (2010)

Modulation of Pro-Inflammatory IL-6 Trans-Signaling Axis by Splice Switching Oligonucleotides as a Therapeutic Modality in Inflammation
Dahkki: Dhanu Gupta, et al.
Almmustuhtton: (2023-09-01)

Cell-penetrating peptides: mechanisms and applications.
Dahkki: El-Andaloussi, S, et al.
Almmustuhtton: (2005)

Peptide-mediated cell and in vivo delivery of antisense oligonucleotides and siRNA
Dahkki: Järver, P, et al.
Almmustuhtton: (2012)

Assessing the uptake kinetics and internalization mechanisms of cell-penetrating peptides using a quenched fluorescence assay.
Dahkki: Mäger, I, et al.
Almmustuhtton: (2010)

Peptide-mediated Cell and In Vivo Delivery of Antisense Oligonucleotides and siRNA
Dahkki: Peter Järver, et al.
Almmustuhtton: (2012-01-01)

Mesyl phosphoramidate oligonucleotides as potential splice-switching agents: impact of backbone structure on activity and intracellular localization
Dahkki: Hammond, SM, et al.
Almmustuhtton: (2021)

Perfluoroaryl Bicyclic Cell-Penetrating Peptides for Delivery of Antisense Oligonucleotides
Dahkki: Wolfe, Justin, et al.
Almmustuhtton: (2020)

Splice-switching antisense oligonucleotides for pediatric neurological disorders
Dahkki: Xiaochang Zhang
Almmustuhtton: (2024-07-01)

Cell-penetrating peptides to enhance delivery of Oligonucleotide-based therapeutics
Dahkki: McClorey, G, et al.
Almmustuhtton: (2018)

NOVEL CELL PENETRATING PEPTIDES FOR SKELETAL AND CARDIAC MUSCLE DELIVERY OF PMO ANTISENSE OLIGONUCLEOTIDES FOR THE TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY
Dahkki: Hammond, S, et al.
Almmustuhtton: (2011)

INNOVATIVE SPLICE SWITCHING OLIGONUCLEOTIDE THERAPY FOR NIEMANN-PICK TYPE C1 DISEASE
Dahkki: Maria Martinez De Lagran, et al.
Almmustuhtton: (2023-10-01)

Cell-penetrating peptide conjugates of steric blocking oligonucleotides as therapeutics for neuromuscular diseases from a historical perspective to current prospects of treatment
Dahkki: Gait, M, et al.
Almmustuhtton: (2018)

Development and validation of AI/ML derived splice-switching oligonucleotides
Dahkki: Alyssa D Fronk, et al.
Almmustuhtton: (2024-04-01)

Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides
Dahkki: Dysko, A, et al.
Almmustuhtton: (2022)

Optimizing tissue-specific antisense oligonucleotide-peptide conjugates.
Dahkki: Betts, C, et al.
Almmustuhtton: (2012)

Potential of Cell-Penetrating Peptide-Conjugated Antisense Oligonucleotides for the Treatment of SMA
Dahkki: Jamie Leckie, et al.
Almmustuhtton: (2024-06-01)

Peptide Conjugates of a 2′‑O‑Methoxyethyl Phosphorothioate Splice-Switching Oligonucleotide Show Increased Entrapment in Endosomes
Dahkki: Alyssa C. Hill, et al.
Almmustuhtton: (2023-10-01)

Uptake kinetics of cell-penetrating peptides.
Dahkki: Florén, A, et al.
Almmustuhtton: (2011)

Cell Penetrating Peptides Used in Delivery of Therapeutic Oligonucleotides Targeting Hepatitis B Virus
Dahkki: Bénédicte Ndeboko, et al.
Almmustuhtton: (2020-12-01)

Cell-penetrating peptide-conjugated antisense oligonucleotides restore systemic muscle and cardiac dystrophin expression and function.
Dahkki: Yin, H, et al.
Almmustuhtton: (2008)

Induction of cryptic pre-mRNA splice-switching by antisense oligonucleotides
Dahkki: Kristin A. Ham, et al.
Almmustuhtton: (2021-07-01)

Applications of cell-penetrating peptides in regulation of gene expression
Dahkki: Järver, P, et al.
Almmustuhtton: (2007)

Applications of cell-penetrating peptides in regulation of gene expression.
Dahkki: Järver, P, et al.
Almmustuhtton: (2007)