Homonojirimycin isomers and N-alkylated homonojirimycins: structural and conformational basis of inhibition of glycosidases.

A series of natural epimers of alpha-homonojirimycin and its N-alkylated derivatives have been prepared to investigate the contribution of the different chiral centers and conformation of the specificity and potency of inhibition of glycosidases. These epimers and N-alkylated derivatives are alpha-h...

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Bibliographic Details
Main Authors: Asano, N, Nishida, M, Kato, A, Kizu, H, Matsui, K, Shimada, Y, Itoh, T, Baba, M, Watson, A, Nash, R, Lilley, P, Watkin, D, Fleet, G
Format: Journal article
Language:English
Published: 1998