Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization.
Members of the p53 tumor suppressor family are expressed as multiple isoforms. Isoforms having an N-terminal transactivation domain are transcriptionally active while those ones lacking this domain often inhibit the transcriptional activity of other family members. In squamous cell carc...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
Nature Publishing Group
2016
|