Genetic variation in the small heterodimer partner gene and young-onset type 2 diabetes, obesity, and birth weight in U.K. subjects.

The orphan receptor small heterodimer partner (SHP, NR0B2) modulates the transcription activity of the MODY1 gene HNF4a. Mutations in SHP were found in 7% of Japanese obese young-onset type 2 diabetic patients and were associated with moderate obesity and increased birth weight. We investigated SHP...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Mitchell, S, Weedon, M, Owen, K, Shields, B, Wilkins-Wall, B, Walker, M, McCarthy, M, Frayling, T, Hattersley, A
Format: Journal article
Język:English
Wydane: 2003