Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping
Structure-guided drug discovery emerged in the 1970s and 1980s, stimulated by the three-dimensional structures of protein targets that became available, mainly through X-ray crystal structure analysis, assisted by the development of synchrotron radiation sources. Structures of known drugs or inhibit...
| Główni autorzy: | , , , , , , , , , , |
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| Format: | Journal article |
| Język: | English |
| Wydane: |
Royal Society
2019
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