Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping
Structure-guided drug discovery emerged in the 1970s and 1980s, stimulated by the three-dimensional structures of protein targets that became available, mainly through X-ray crystal structure analysis, assisted by the development of synchrotron radiation sources. Structures of known drugs or inhibit...
Hlavní autoři: | Thomas, SE, Collins, P, James, RH, Mendes, V, Charoensutthivarakul, S, Radoux, C, Abell, C, Coyne, AG, Floto, RA, Von Delft, F, Blundell, TL |
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Médium: | Journal article |
Jazyk: | English |
Vydáno: |
Royal Society
2019
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