Structure determination of noncanonical RNA motifs guided by ¹H NMR chemical shifts.

Structure determination of noncanonical RNA motifs guided by ¹H NMR chemical shifts.

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Structured noncoding RNAs underlie fundamental cellular processes, but determining their three-dimensional structures remains challenging. We demonstrate that integrating ¹H NMR chemical shift data with Rosetta de novo modeling can be used to consistently determine high-resolution RNA structures. On...

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Bibliografiska uppgifter
Huvudupphovsmän: Sripakdeevong, P, Cevec, M, Chang, A, Erat, M, Ziegeler, M, Zhao, Q, Fox, G, Gao, X, Kennedy, S, Kierzek, R, Nikonowicz, E, Schwalbe, H, Sigel, R, Turner, D, Das, R
Materialtyp: Journal article
Språk:English
Publicerad: 2014

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