Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection

Female children and adults typically generate more efficacious immune responses to vaccines and infections than age-matched males, but also suffer greater immunopathology and autoimmune disease. We here describe, in a cohort of > 170 in utero HIV-infected infants from KwaZulu-Natal, South Africa,...

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Main Authors:	Adland, E, Millar, J, Bengu, N, Muenchhoff, M, Fillis, R, Sprenger, K, Ntlantsana, V, Roider, J, Vieira, V, Govender, K, Adamson, J, Nxele, N, Ochsenbauer, C, Kappes, J, Mori, L, van Lobenstein, J, Graza, Y, Chinniah, K, Kapongo, C, Bhoola, R, Krishna, M, Matthews, PC, Poderos, RP, Lluch, MC, Puertas, MC, Prado, JG, McKerrow, N, Archary, M, Ndung'u, T, Groll, A, Jooste, P, Martinez-Picado, J, Altfeld, M, Goulder, P
Format:	Journal article
Language:	English
Published:	Springer Nature 2020

Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection

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