Analysis of potassium (K+) efflux systems (Kef) as an antibiotic target in pathogenic bacteria

Analysis of potassium (K+) efflux systems (Kef) as an antibiotic target in pathogenic bacteria

<p>Potassium (K<sup>+</sup>) efflux systems (Kef) are K<sup>+</sup>/H<sup>+</sup> antiporters found in most Gram-negative bacteria. Kef systems play a vital role in the protection of bacteria from toxic electrophiles by regulating cytoplasmic pH and conseque...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Haslam, C
Awduron Eraill:	Conway, S
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2019
Pynciau:	Organic Chemistry Biochemistry Medicinal Chemistry Biological Chemistry Chemical Biology

Eitemau Tebyg

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Targeting the Ras superfamily via their regulatory GEF complexes
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Synthesis of Mycobacterium tuberculosis ATP synthase inhibitors
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The development of small molecule inhibitors of the essential Leishmania bromodomain LdBDF5
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Novel methods in glycosaminoglycan and proteoglycan synthesis
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Towards a small molecule inhibitor of Lactate Dehydrogenase-A
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Novel protein editing technologies to probe cellular damage
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Design and synthesis of small molecule chemical probes for bromodomain-containing proteins.
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Design and synthesis of nanoparticles functionalised with Lewis oligosaccharides for selective targeting of DC-SIGN
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Interplay between 2-oxoglutarate oxygenases and cancer: studies on the aspartyl/asparaginyl-beta-hydroxylase
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