Different mechanisms underlie the long‐term regulation of pyruvate dehydrogenase kinase (PDHK) by tri‐iodothyronine in heart and liver

Different mechanisms underlie the long‐term regulation of pyruvate dehydrogenase kinase (PDHK) by tri‐iodothyronine in heart and liver

Antibodies to purified recombinant PDHKII were used for ELISAs of PDHKII in mitochondrial extracts. In liver, hyperthyroidism elicited a 2.3‐fold increase in PDHK activity (P<0.01) which was accompanied by a significant 1.5‐fold (P<0.001) increase in the amount of mitochondrial immunor...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí:	Priestman, D, Donald, E, Holness, M, al., E
Formáid:	Journal article
Foilsithe / Cruthaithe:	Wiley 1997

Míreanna comhchosúla

Inhibition of pyruvate dehydrogenase kinase by pyruvate in cultured cardiac myocytes
de réir: Priestman, D, et al.
Foilsithe / Cruthaithe: (1997)

Role of protein synthesis and of fatty acid metabolism in the longer-term regulation of pyruvate dehydrogenase kinase
de réir: Priestman, D, et al.
Foilsithe / Cruthaithe: (1994)

Transcriptional Regulation of Pyruvate Dehydrogenase Kinase
de réir: Ji Yun Jeong, et al.
Foilsithe / Cruthaithe: (2012-10-01)

Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma.
de réir: Koukourakis, M, et al.
Foilsithe / Cruthaithe: (2005)

The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
de réir: In-Kyu Lee
Foilsithe / Cruthaithe: (2014-06-01)

Pyruvate Dehydrogenase and Pyruvate Dehydrogenase Kinase Expression in Non Small Cell Lung Cancer and Tumor-Associated Stroma
de réir: Michael I. Koukourakis, et al.
Foilsithe / Cruthaithe: (2005-01-01)

Pyruvate Dehydrogenase Kinase as a Novel Therapeutic Target in Oncology
de réir: Gopinath eSutendra, et al.
Foilsithe / Cruthaithe: (2013-03-01)

Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
de réir: Nam Ho Jeoung
Foilsithe / Cruthaithe: (2015-06-01)

Pyruvate Dehydrogenase Kinase 4: A Key Mediator for Metabolic Regulation of Liver Regeneration
de réir: James Burdick, et al.
Foilsithe / Cruthaithe: (2020-04-01)

The inhibitory effect of salmon calcitonin on tri-iodothyronine induction of early hypertrophy in articular cartilage.
de réir: Pingping Chen-An, et al.
Foilsithe / Cruthaithe: (2012-01-01)

Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis
de réir: Mariana Galvão Ferrarini, et al.
Foilsithe / Cruthaithe: (2021-02-01)

Low tri-iodothyronine syndrome improves the risk prediction for mortality in patients with acute heart failure: A prospective observational cohort study
de réir: Shen-Gen Liao, et al.
Foilsithe / Cruthaithe: (2021-01-01)

The Tri-iodothyronine (T3) Level Is a Prognostic Factor for Patients With Advanced NSCLC: Receiving Immune Checkpoint Inhibitors and Is Associated With Liver Metastasis
de réir: Yoonjoo Kim, et al.
Foilsithe / Cruthaithe: (2022-12-01)

Pyruvate dehydrogenase kinase regulates macrophage polarization in metabolic and inflammatory diseases
de réir: Chenyu Li, et al.
Foilsithe / Cruthaithe: (2023-12-01)

Mechanisms of Vascular Calcification: The Pivotal Role of Pyruvate Dehydrogenase Kinase 4
de réir: Jaechan Leem, et al.
Foilsithe / Cruthaithe: (2016-03-01)

Deficiency of pyruvate dehydrogenase kinase 4 sensitizes mouse liver to diethylnitrosamine and arsenic toxicity through inducing apoptosis
de réir: Jonathan Choiniere, et al.
Foilsithe / Cruthaithe: (2018-06-01)

Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk
de réir: Forteza, MJ, et al.
Foilsithe / Cruthaithe: (2023)

Dichloroacetate, an inhibitor of pyruvate dehydrogenase kinases, inhibits platelet aggregation and arterial thrombosis
de réir: Manasa K. Nayak, et al.
Foilsithe / Cruthaithe: (2018-08-01)

Fasting and Glucagon Stimulate Gene Expression of Pyruvate Dehydrogenase Kinase 4 in Chickens
de réir: Kazuhisa Honda, et al.
Foilsithe / Cruthaithe: (2017-10-01)

Overexpression of Pyruvate Dehydrogenase Kinase-3 Predicts Poor Prognosis in Urothelial Carcinoma
de réir: Yu-Hsuan Kuo, et al.
Foilsithe / Cruthaithe: (2021-09-01)

The Aspergillus nidulans Pyruvate Dehydrogenase Kinases Are Essential To Integrate Carbon Source Metabolism
de réir: Laure Nicolas Annick Ries, et al.
Foilsithe / Cruthaithe: (2018-07-01)

Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism
de réir: Sungmi Park, et al.
Foilsithe / Cruthaithe: (2018-08-01)

Is It T3 Thyrotoxicosis? A Case of Falsely Elevated Tri-Iodothyronine (T3) Levels Leading to a Diagnosis of Multiple Myeloma
de réir: Nanik Ram, et al.
Foilsithe / Cruthaithe: (2019-01-01)

Comparison of serum levels of Tri‐iodothyronine (T3), Thyroxine (T4), and Thyroid‐Stimulating Hormone (TSH) in preeclampsia and normal pregnancy
de réir: Nayereh Khadem, et al.
Foilsithe / Cruthaithe: (2012-01-01)

Inhibition of Pyruvate Dehydrogenase in the Heart as an Initiating Event in the Development of Diabetic Cardiomyopathy
de réir: Abdallah Elnwasany, et al.
Foilsithe / Cruthaithe: (2023-03-01)

Iodothyronine deiodinases and reduced sensitivity to thyroid hormones
de réir: Rosa Maria Paragliola, et al.
Foilsithe / Cruthaithe: (2020-01-01)

Novel Dichloroacetophenone-Based PDHK1 Inhibitors as Potent Anticancer Agents
de réir: Wu P, et al.
Foilsithe / Cruthaithe: (2024-10-01)

Pyruvate dehydrogenase kinase 4 promotes ubiquitin–proteasome system‐dependent muscle atrophy
de réir: Ibotombi Singh Sinam, et al.
Foilsithe / Cruthaithe: (2022-12-01)

Comparison of docking procedures and its efficiency for Betasecretase, Aromatase and Pyruvate dehydrogenase kinase inhibitors
de réir: Zahra Rezaei, et al.
Foilsithe / Cruthaithe: (2017-03-01)

Genetic inactivation of pyruvate dehydrogenase kinases improves hepatic insulin resistance induced diabetes.
de réir: Rongya Tao, et al.
Foilsithe / Cruthaithe: (2013-01-01)

Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype
de réir: Byong-Keol Min, et al.
Foilsithe / Cruthaithe: (2019-05-01)

Modulation of Muscle Fiber Compositions in Response to Hypoxia via Pyruvate Dehydrogenase Kinase-1
de réir: Daniel Nguyen, et al.
Foilsithe / Cruthaithe: (2016-12-01)

Comparison of docking procedures and its efficiency for Betasecretase, Aromatase and Pyruvate dehydrogenase kinase inhibitors
de réir: Zahra Rezaei, et al.
Foilsithe / Cruthaithe: (2017-03-01)

Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes
de réir: Md Habibur Rahman, et al.
Foilsithe / Cruthaithe: (2020-11-01)

Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation
de réir: Allison K. Meyers, et al.
Foilsithe / Cruthaithe: (2023-01-01)

Pyruvate Dehydrogenase A1 Phosphorylated by Insulin Associates with Pyruvate Kinase M2 and Induces LINC00273 through Histone Acetylation
de réir: Abu Jubayer Hossain, et al.
Foilsithe / Cruthaithe: (2022-05-01)

Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers
de réir: Nilanjana Chatterjee, et al.
Foilsithe / Cruthaithe: (2019-08-01)

Regulation of type 1 iodothyronine deiodinase by LXRα.
de réir: Yoriko Sakane, et al.
Foilsithe / Cruthaithe: (2017-01-01)

Effect of Iodothyronines on Thermogenesis: Focus on Brown Adipose Tissue
de réir: Federica Cioffi, et al.
Foilsithe / Cruthaithe: (2018-05-01)

A Halogen Bonding Perspective on Iodothyronine Deiodinase Activity
de réir: Eric S. Marsan, et al.
Foilsithe / Cruthaithe: (2020-03-01)