Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.

The von Hippel-Lindau tumor suppressor protein (pVHL) has emerged as a key factor in cellular responses to oxygen availability, being required for the oxygen-dependent proteolysis of alpha subunits of hypoxia inducible factor-1 (HIF). Mutations in VHL cause a hereditary cancer syndrome associated wi...

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Bibliografiske detaljer
Main Authors: Cockman, M, Masson, N, Mole, D, Jaakkola, P, Chang, G, Clifford, S, Maher, E, Pugh, C, Ratcliffe, P, Maxwell, P
Format: Journal article
Sprog:English
Udgivet: 2000