Transcriptional regulation of the endogenous danger signal tenascin-C: a novel autocrine loop in inflammation.

Inappropriate expression of proinflammatory mediators underpins the pathogenesis of autoimmune disease and tumor metastasis. The extracellular matrix glycoprotein tenascin-C is an endogenous activator of innate immunity that promotes the synthesis of inflammatory cytokines via activation of TLR4. Li...

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Bibliographic Details
Main Authors: Goh, F, Piccinini, A, Krausgruber, T, Udalova, I, Midwood, K
Format: Journal article
Language:English
Published: 2010