Transcriptional regulation of the endogenous danger signal tenascin-C: a novel autocrine loop in inflammation.
Inappropriate expression of proinflammatory mediators underpins the pathogenesis of autoimmune disease and tumor metastasis. The extracellular matrix glycoprotein tenascin-C is an endogenous activator of innate immunity that promotes the synthesis of inflammatory cytokines via activation of TLR4. Li...
Main Authors: | , , , , |
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Format: | Journal article |
Language: | English |
Published: |
2010
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