Naïve-pooled pharmacokinetic analysis of pyrazinamide, isoniazid and rifampicin in plasma and cerebrospinal fluid of Vietnamese children with tuberculous meningitis

<p>Among the various forms of TB, tuberculous meningitis (TBM) is the most severe, with about 30 % mortality and 50 % of survivors left with neurological sequelae. Children suffer more frequently from TBM than adults and outcomes are often poor due to difficulties in making the diagnosis and u...

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Bibliographic Details
Main Authors: Pouplin, T, Bang, N, Toi, P, Phuong, P, Dung, N, Duong, T, Caws, M, Thwaites, G, Tarning, J, Day, J
Format: Journal article
Published: BioMed Central 2016