Development of bisulfite-free DNA methylation sequencing methods and their application to cell-free DNA for cancer detection
<p>5-Methylcytosine (5mC) is the most abundant epigenetic mark in DNA regulating gene expression and influencing crucial cellular processes. Aberrant DNA methylation is involved in pathogenesis of human malignancies. Detection of cancer-specific methylation patterns in cell-free DNA (cfDNA) is...
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| Format: | Thesis |
| Language: | English |
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2020
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