Adenovirus gene transfer causes inflammation in the brain.
We report that injecting an E1-deleted, non-replicating, human adenovirus type 5 vector into the brain leads to an inflammatory response. Much of this inflammation is induced directly by the virion particles themselves rather than through the expression of new proteins from the vector. The severity...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1995
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