Development and application of ligand-based NMR screening assays for γ-butyrobetaine hydroxylase
γ-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate (2OG) dependent oxygenase that catalyses the stereoselective C-3 hydroxylation of γ-butyrobetaine (GBB) to give L-carnitine. L-carnitine is involved in fatty acid metabolism in all animals and in some prokaryotes, and BBOX is a current drug targ...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Published: |
Royal Society of Chemistry
2016
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