Fine-mapping of colorectal cancer susceptibility loci at 8q23.3, 16q22.1 and 19q13.11: refinement of association signals and use of in silico analysis to suggest functional variation and unexpected candidate target genes.

Fine-mapping of colorectal cancer susceptibility loci at 8q23.3, 16q22.1 and 19q13.11: refinement of association signals and use of in silico analysis to suggest functional variation and unexpected candidate target genes.

We have previously identified several colorectal cancer (CRC)-associated polymorphisms using genome-wide association (GWA) analysis. We sought to fine-map the location of the functional variants for three of these regions at 8q23.3 (EIF3H), 16q22.1 (CDH1/CDH3) and 19q13.11 (RHPN2). We genotyped two...

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Bibliographic Details
Main Authors: Carvajal-Carmona, L, Cazier, J, Jones, A, Howarth, K, Broderick, P, Pittman, A, Dobbins, S, Tenesa, A, Farrington, S, Prendergast, J, Theodoratou, E, Barnetson, R, Conti, D, Newcomb, P, Hopper, J, Jenkins, M, Gallinger, S, Duggan, D, Campbell, H, Kerr, D, Casey, G, Houlston, R, Dunlop, M, Tomlinson, I
Format: Journal article
Language:English
Published: 2011

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