IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis.
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract that is caused in part by a dysregulated immune response to the intestinal flora. The common interleukin (IL)-12/IL-23p40 subunit is thought to be critical for the pathogenesis of IBD. We have analyzed...
| Autors principals: | , , , , , , , , , , |
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| Format: | Journal article |
| Idioma: | English |
| Publicat: |
2006
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| _version_ | 1826290226472943616 |
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| author | Kullberg, M Jankovic, D Feng, C Hue, S Gorelick, P McKenzie, B Cua, D Powrie, F Cheever, A Maloy, K Sher, A |
| author_facet | Kullberg, M Jankovic, D Feng, C Hue, S Gorelick, P McKenzie, B Cua, D Powrie, F Cheever, A Maloy, K Sher, A |
| author_sort | Kullberg, M |
| collection | OXFORD |
| description | Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract that is caused in part by a dysregulated immune response to the intestinal flora. The common interleukin (IL)-12/IL-23p40 subunit is thought to be critical for the pathogenesis of IBD. We have analyzed the role of IL-12 versus IL-23 in two models of Helicobacter hepaticus-triggered T cell-dependent colitis, one involving anti-IL-10R monoclonal antibody treatment of infected T cell-sufficient hosts, and the other involving CD4+ T cell transfer into infected Rag-/- recipients. Our data demonstrate that IL-23 and not IL-12 is essential for the development of maximal intestinal disease. Although IL-23 has been implicated in the differentiation of IL-17-producing CD4+ T cells that alone are sufficient to induce autoimmune tissue reactivity, our results instead support a model in which IL-23 drives both interferon gamma and IL-17 responses that together synergize to trigger severe intestinal inflammation. |
| first_indexed | 2024-03-07T02:40:56Z |
| format | Journal article |
| id | oxford-uuid:aa6f60db-0b6f-49d5-92f2-278f19e9d0ad |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:40:56Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:aa6f60db-0b6f-49d5-92f2-278f19e9d0ad2022-03-27T03:14:59ZIL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:aa6f60db-0b6f-49d5-92f2-278f19e9d0adEnglishSymplectic Elements at Oxford2006Kullberg, MJankovic, DFeng, CHue, SGorelick, PMcKenzie, BCua, DPowrie, FCheever, AMaloy, KSher, AInflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract that is caused in part by a dysregulated immune response to the intestinal flora. The common interleukin (IL)-12/IL-23p40 subunit is thought to be critical for the pathogenesis of IBD. We have analyzed the role of IL-12 versus IL-23 in two models of Helicobacter hepaticus-triggered T cell-dependent colitis, one involving anti-IL-10R monoclonal antibody treatment of infected T cell-sufficient hosts, and the other involving CD4+ T cell transfer into infected Rag-/- recipients. Our data demonstrate that IL-23 and not IL-12 is essential for the development of maximal intestinal disease. Although IL-23 has been implicated in the differentiation of IL-17-producing CD4+ T cells that alone are sufficient to induce autoimmune tissue reactivity, our results instead support a model in which IL-23 drives both interferon gamma and IL-17 responses that together synergize to trigger severe intestinal inflammation. |
| spellingShingle | Kullberg, M Jankovic, D Feng, C Hue, S Gorelick, P McKenzie, B Cua, D Powrie, F Cheever, A Maloy, K Sher, A IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. |
| title | IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. |
| title_full | IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. |
| title_fullStr | IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. |
| title_full_unstemmed | IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. |
| title_short | IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. |
| title_sort | il 23 plays a key role in helicobacter hepaticus induced t cell dependent colitis |
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