Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit.

Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit.

ATP-sensitive potassium (KATP) channels couple cell metabolism to electrical activity by regulating K+ flux across the plasma membrane. Channel closure is mediated by ATP, which binds to the pore-forming subunit (Kir6.2). Here we use homology modelling and ligand docking to construct a model of the...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Antcliff, J, Haider, S, Proks, P, Sansom, MS, Ashcroft, F
التنسيق:	Journal article
اللغة:	English
منشور في:	2005

مواد مشابهة

Mapping the architecture of the ATP-binding site of the KATP channel subunit Kir6.2.
حسب: Dabrowski, M, وآخرون
منشور في: (2004)

Focus on Kir6.2: a key component of the ATP-sensitive potassium channel.
حسب: Haider, S, وآخرون
منشور في: (2005)

Involvement of the N-terminus of Kir6.2 in the inhibition of the KATP channel by ATP.
حسب: Proks, P, وآخرون
منشور في: (1999)

A mutation in the ATP-binding site of the Kir6.2 subunit of the KATP channel alters coupling with the SUR2A subunit.
حسب: Tammaro, P, وآخرون
منشور في: (2007)

Phentolamine block of KATP channels is mediated by Kir6.2.
حسب: Proks, P, وآخرون
منشور في: (1997)

Identification of residues contributing to the ATP binding site of Kir6.2.
حسب: Trapp, S, وآخرون
منشور في: (2003)

Direct photoaffinity labeling of the Kir6.2 subunit of the ATP-sensitive K+ channel by 8-azido-ATP.
حسب: Tanabe, K, وآخرون
منشور في: (1999)

Mapping the architecture of the ATP-binding site of Kir6.2
حسب: Dabrowski, M, وآخرون
منشور في: (2002)

Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel.
حسب: Reimann, F, وآخرون
منشور في: (2001)

The role of lysine 185 in the kir6.2 subunit of the ATP-sensitive channel in channel inhibition by ATP.
حسب: Reimann, F, وآخرون
منشور في: (1999)

Screening for mutations in the Kir6.2 subunit of the beta-cell K-ATP channel
حسب: Sakura, H, وآخرون
منشور في: (1996)

Interaction of the cytosolic domains of the Kir6.2 subunit of the K(ATP) channel is modulated by sulfonylureas.
حسب: Lippiat, J, وآخرون
منشور في: (2002)

Behavioral phenotyping of mice lacking the K ATP channel subunit Kir6.2.
حسب: Deacon, R, وآخرون
منشور في: (2006)

Behavioral phenotyping of mice lacking the K ATP channel subunit Kir6.2.
حسب: Deacon, R, وآخرون
منشور في: (2006)

The Kir6.2-F333I mutation differentially modulates KATP channels composed of SUR1 or SUR2 subunits.
حسب: Tammaro, P, وآخرون
منشور في: (2007)

3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1.
حسب: Mikhailov, M, وآخرون
منشور في: (2005)

Filter flexibility in a mammalian K channel: models and simulations of Kir6.2 mutants.
حسب: Capener, C, وآخرون
منشور في: (2003)

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes.
حسب: Gloyn, A, وآخرون
منشور في: (2004)

Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.
حسب: Girard, C, وآخرون
منشور في: (2009)

Pyridine nucleotide regulation of the KATP channel Kir6.2/SUR1 expressed in Xenopus oocytes.
حسب: Dabrowski, M, وآخرون
منشور في: (2003)

Glimepiride block of Kir6.2/SUR1 Kir6.2/SUR2A and Kir6.2/SUR2A and Kir6.2/SUR2B K-ATP channels.
حسب: Ashcroft, F, وآخرون
منشور في: (2001)

Time-dependent activation of Kir6.2/SUR2A channels but not Kir6.2/SUR1 channels in the presence of ATP
حسب: Ashcroft, F, وآخرون
منشور في: (2001)

Identification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysis.
حسب: Haider, S, وآخرون
منشور في: (2007)

Mutations within the P-loop of Kir6.2 modulate the intraburst kinetics of the ATP-sensitive potassium channel.
حسب: Proks, P, وآخرون
منشور في: (2001)

Time-dependent activation of KIR6.2/SUR2A channels but not KIR6.2/SUR1 channels in the presence of MgATP
حسب: Song, D, وآخرون
منشور في: (2001)

Photobiomodulation on KATP Channels of Kir6.2-Transfected HEK-293 Cells
حسب: Fu-qing Zhong, وآخرون
منشور في: (2014-01-01)

Structure-function studies of the fast gating kinetics of the cloned ATP-sensitive potassium channel, Kir6.2/SUR1
حسب: Proks, P, وآخرون
منشور في: (2001)

Reduced expression of Kir6.2/SUR2A subunits explains KATP deficiency in K+-depleted rats.
حسب: Tricarico, D, وآخرون
منشور في: (2008)

Molecular determinants of KATP channel inhibition by ATP.
حسب: Tucker, S, وآخرون
منشور في: (1998)

Kir6.2-dependent high-affinity repaglinide binding to beta-cell K(ATP) channels.
حسب: Hansen, A, وآخرون
منشور في: (2005)

Molecular basis of Kir6.2 mutations causing neonatal diabetes and neonatal diabetes with neurological features
حسب: Proks, P, وآخرون
منشور في: (2005)

Overlapping distribution of K(ATP) channel-forming Kir6.2 subunit and the sulfonylurea receptor SUR1 in rodent brain.
حسب: Karschin, C, وآخرون
منشور في: (1997)

A gating mutation at the internal mouth of the Kir6.2 pore is associated with DEND syndrome.
حسب: Proks, P, وآخرون
منشور في: (2005)

Structure of an open KATP channel reveals tandem PIP2 binding sites mediating the Kir6.2 and SUR1 regulatory interface
حسب: Camden M. Driggers, وآخرون
منشور في: (2024-03-01)

The Kir6.2-F333I mutation differentially modulates K-ATP channels composed of SUR1 or SUR2 subunits
حسب: Tammaro, P, وآخرون
منشور في: (2007)

The Kir6.2-F333I mutation differentially modulates K ATP channels composed of SUR1 and SUR2 subunits
حسب: Tammaro, P, وآخرون
منشور في: (2007)

Direct photoaffinity labeling of Kir6.2 by [gamma-(32)P]ATP-[gamma]4-azidoanilide.
حسب: Tanabe, K, وآخرون
منشور في: (2000)

Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological features.
حسب: Proks, P, وآخرون
منشور في: (2004)

Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor.
حسب: Tucker, S, وآخرون
منشور في: (1997)

A novel SUR1/Kir6.2 specific K-ATP channel opener
حسب: Dabrowski, M, وآخرون
منشور في: (2001)