Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit.

Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit.

ATP-sensitive potassium (KATP) channels couple cell metabolism to electrical activity by regulating K+ flux across the plasma membrane. Channel closure is mediated by ATP, which binds to the pore-forming subunit (Kir6.2). Here we use homology modelling and ligand docking to construct a model of the...

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Chi tiết về thư mục
Những tác giả chính:	Antcliff, J, Haider, S, Proks, P, Sansom, MS, Ashcroft, F
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	2005

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